Objectives: The aim of the study was to incidence thalassemia minor by determining HbA2 levels in pregnant females attending Obstetrics and Gynaecology OPD husbands positive for beta-thalassemia trait. Methods: prospective spanning over 1½ years conducted Department Pathology 1020 who attended Government Medical College, Patiala antenatal check-up. any trimester without specific sign symptoms w...

By W. N. POWELL, M.D., J. G. RODARTE, M.D., AND J. V. NEEL, PH.D., M.D. A LTHOUGH in recent years the blood disorders sickle cell disease and thalassemia have both been studied extensively from the genetic standpoint, thus far the simultaneous occurrence within a single family group of the genes responsible for these two diseases has not been reported in the medical literature of the United Sta...

We have previously described an English family with ‘y#{244} thalassemia in which a large deletion stops 25 kilobases (kb) upstream from the fl-globin gene locus. and yet the fi-globin gene is inactive in vivo. Affected family members had a fi-thalassemia minor phenotype with a normal hemoglobin A2 level. Gene mapping showed that these subjects were heterozygous for a chromosome bearing a large...

There are numerous studies presenting the beneficial effect of bisphosphonates (BPs) on bone disease of patients suffering from beta-thalassemia major (TM). Although BPs have been widely used, adverse events have been described including atypical femoral fractures (AFF). In the present case, a male adult patient suffering from TM sustained an AFF fulfilling all major and two minor criteria. Bef...

Background: Osteoporosis is one of the late complications of β-Thalassemia major. The pathogenesis of osteoporosis depends on different factors. Ineffectiveness of hematopoiesis is the major factor, and the other factors are defected by hormonal functions or biochemical parameters. Osteoclasts hyperactivity in thalassemia increases the serum receptor activator of nuclear factor Kappa B ligand (...