no. 1 DISEASE-MODIFYING EFFECTS OF RESVERATROL IN THE 3XTG-AD MOUSE MODEL OF ALZHEIMER’S DISEASE A. DAL-PAN , C. JULIEN , C. PIERRISNARD , C. TREMBLAY , F. CALON Axes Neurosciences, Centre de recherche du centre hospitalier de l’Université Laval (CHUQ), Québec, QC, Canada . Background: There is a general agreement that disease-modifying treatments will be required for Alzheimer's disease (AD). ...

exercise training has been shown to decrease chronic low- grade systemic inflammation in high- fat diet induced obesity. however, the mechanisms mediating its beneficial effects are not fully understood. therefore, the aim of this study was to investigate the effects of a 12- week endurance training on il-6, il-10 and nesfatin -1 in obese male rats. sixteen male wistar rats (2 months old) were ...

Clenbuterol was administered as a dietary admixture (4 mg/kg diet) to three groups of male Wistar rats (n = 8) housed individually in metabolism cages and fed for 15 d at 110, 160, and 235% (ad libitum) of estimated requirement for energy maintenance. Untreated groups at each level of energy intake were also included. There was no effect of clenbuterol on food intake in the ad libitum group, bu...

The present study was performed in order to discern the effects of propylthiouracil (PTU) on ethanol and/or protein deficiency-mediated liver histological changes and liver Fe, Zn, Cu and Mn alterations in male adult Wistar rats. The study was performed on 64 animals divided into eight groups, fed with the Leiber-DeCarli control, 36% ethanol-2% protein- and 36% ethanol-2% protein-containing die...

The effects of magnesium or zinc deficiency on growth, tissue contents of Mg or Zn and protein synthesis have been compared in 4-13-week-old rats. When maintained on Mg-deficient fodder (1.6 mmol/kg) or Zn-deficient fodder (27 mumol/kg) rats showed a reduced weight gain, whereas repletion caused increased growth rates. Pair-feeding experiments showed that this could not be attributed to reduced...

Rates of production and oxidation of ruminal acetate were measured in young sheep (1) infected with T. colubriformis; (2) kept worm-free and pair-fed to (1); and (3) kept worm-free and given feed ad lib. Both voluntary food consumption and the production rate of acetate were reduced by up to 76 per cent in sheep on treatment (1) compared with (3). Acetate production rate was 30 per cent lower i...

Objective: Frankincense improves memory in different models of learning. However, its influence on models of Alzheimer's disease (AD) has not been studied widely. In the present study, the therapeutic effect of frankincense was evaluated in a model of AD induced by i.c.v administration of streptozotocin. Materials and Methods: Under stereotaxic surgery, two guide cannulas were implanted in the ...

Some metabolic indicators of thyroid hormone activity have been investigated in rats fed on either protein-deficient or energy-restricted diets. Rats were divided into three groups. Control animals were maintained on a diet of protein energy: total energy (P:E) value of 0.20, while the low-protein group (LP) were allowed ad lib. access to food of P:E 0.03. Energy-restricted (ER) rats were given...

In two experiments, the effects of caloric restriction during the postini tiation phase of pancreatic carcinogenesis were evaluated. Male Lewis rats were given injections of azaserine at 14 days of age and weaned to the postinitiation test protocols at 21 days of age. In the first experiment, the caloric content of the diets was restricted by 10, 15, 20, and 30% of the intakes of the ad libitum...

An important question about traditional caloric restriction (CR) experiments on laboratory mice is how food intake in the laboratory compares with that of wild mice in nature. Such knowledge would allow us to distinguish between two opposing views of the anti-aging effect of CR--whether CR represents, in laboratory animals, a return to a more normal level of food intake, compared with excess fo...