Metaplasticity regulates the threshold for modification of synaptic strength and is an important regulator of learning rules; however, it is not known whether these cellular mechanisms for homeostatic regulation of synapses contribute to particular forms of learning. Conditional ablation of mGluR5 in CA1 pyramidal neurons resulted in the inability of low-frequency trains of afferent activation ...

Oscillations in the X-ray flux of thermonuclear X-ray bursts have been observed with RXTE from at least 6 low-mass binaries, at frequencies from 330 Hz to 589 Hz. There appear to be preferred relations between the frequencies present during the bursts and those seen in the persistent flux. The amplitude of the oscillations can exceed 50 % near burst onset. Except for a systematic increase in os...

— The spectra of the majority of bursts exhibit a low-energy power law index, α, that is either a constant or becomes softer with time. However, in the burst of 30 May 1996 α becomes harder. Here we show that this behavior can be explained by a hybrid model consisting of a thermal and a non-thermal component. In this burst the power-law index of the non-thermal component changes drastically fro...

Since the discovery of the accreting millisecond pulsar XTE J1814-338 a total of 27 thermonuclear bursts have been observed from the source with the Proportional Counter Array (PCA) onboard the Rossi X-ray Timing Explorer (RXTE). Spectroscopy of the bursts, as well as the presence of continuous burst oscillations, suggests that all but one of the bursts are sub-Eddington. The remaining burst ha...

A novel hot embossing/low temperature ethanol solvent bonding method for the fabrication of polymethylmethacrylate (PMMA) field flow fractionation devices has been developed. The separation channel on a PMMA substrate was generated by a hot embossing process without vacuum. Special temperature-pressure profiles were used to analyze the influence of the hot embossing parameters. After the hot em...

Transcription is a stochastic process occurring mostly in episodic bursts. Although the local chromatin environment is known to influence the bursting behavior on long timescales, the impact of transcription factors (TFs)--especially in rapidly inducible systems--is largely unknown. Using fluorescence in situ hybridization and computational models, we quantified the transcriptional activity of ...

The influence of operating variables [viz: temperature 55-85°C, process time 30-120 min, pH 9-11,peraceticacid concentration 0.5-3.5% oven dried pulp (o.d.p.)., and sodium perborate concentration 1-5% o.d.p.] on the bleached pulp characteristics [viz: viscosity (VI), brightness (BR), kappa number (KN)], and resulting paper sheets properties [viz: breaking length (BL), stretch (ST), tear (TI), a...

High-frequency activity produces transient depression at many synapses but also, as recently demonstrated, may accelerate the recovery from use-dependent depression. We have examined the possible consequences of this synaptic mechanism in neocortical excitatory synapses by recording simultaneously from presynaptic pyramidal neurons and their postsynaptic targets. Brief bursts of high-frequency ...