Nanohybrids using biocompatible and biodegradable materials are explored for their photothermal mediated theranostic applications. These hybrids so chosen that they biodegradable. Gold-based different nanosystems have NIR absorption which is highly favored PTT, but limited by toxicity, stability, clearance. To overcome these challenges, we demonstrated thermosensitive liposome-gold hybrid nanos...

Compared with other diagnostic methods, ultrasound is proven to be a safe, simple, non-invasive and cost-effective imaging technique, but the resolution is not comparable to that of magnetic resonance imaging (MRI). Contrast-enhanced ultrasound employing microbubbles can gain a better resolution and is now widely used to diagnose a number of diseases in the clinic. For the last decade, microbub...

Nanotechnology has enabled the development of smart theranostic platforms that can concurrently diagnose disease, start primary treatment, monitor response, and, if required, initiate secondary treatments. Recent in vivo experiments demonstrate the promise of using theranostics in the clinic. In this paper, we review the use of remotely triggered theranostic nanoparticles for cancer application...

The concept of targeted radionuclide therapy (TRT) relies on the use of injected nuclear medicine as treating agents, targeted at the cellular or molecular level. The growth of the interest in TRT was stimulated by the advances in radionuclide production and labeling as well as by the improvement in the knowledge of appropriate and specific molecular targets. In recent years, different studies ...

A biocompatible, multimodal, and theranostic functional iron oxide nanoparticle is synthesized using a novel water-based method and exerts excellent properties for targeted cancer therapy, and optical and magnetic resonance imaging. For the first time, a facile, modified solvent diffusion method is used for the co-encapsulation of both an anticancer drug and near-infrared dyes. The resulting fo...

Biological molecules such as DNA, proteins, and lipids can be assembled into naturally existing nanoparticles, bacterial viruses (also called bacteriophages or phages), plant viruses, nucleic acid nanoparticles (e.g., DNA origami), protein exosomes. These bionanoparticles have their own distinct properties (including compositions, structures, shapes, functions), laying the foundation for unique...

The advent of targeted therapies generated much optimism when discovered. Targeted therapies, are however associated with rapid acquisition of resistance. In a recent study by Dong et al. (Theranostics 2018; 8(7):1808-1823. doi:10.7150/thno.23177) it was shown that lung tumors resistant to the EGFR-inhibitor (Erlotinib), reprogram their metabolism and acquire a pro-survival dependency on Phosph...