The conceptual divide separating the physical and biological sciences continues to challenge modern science. In this perspective it is proposed that the two sciences can be directly connected through the fundamental concept of stability. Physicochemical stability is shown to have a logical, rather than an empirical basis, and able to manifest itself in two distinct and often contrary ways, one ...

Comparison of the conformational stability of an O(6)-methylguanine-DNA methyltransferase (MGMT) from the hyperthermophilic archaeon Thermococcus kodakaraensis strain KOD1 (Tk-MGMT), and its mesophilic counterpart C-terminal Ada protein from Escherichia coli (Ec-AdaC) was performed in order to obtain information about the relationship between thermal stability and other factors, such as thermod...

p18 is a member of the INK4 family of proteins that regulate the G1 to S cell cycle transition by binding to and inhibiting the pRb kinase activity of cyclindependent kinases 4 and 6. The p16 member of the INK4 protein family is altered in a variety of cancers and structure-function studies of the INK4 proteins reveal that the vast majority of missense tumor-derived p16 mutations reduce protein...

Context. To investigate the physical nature of the 'nucleated instability' of proto giant planets, the stability of layers in static, radiative gas spheres is analysed on the basis of Baker's standard one-zone model. Aims. It is shown that stability depends only upon the equations of state, the opacities and the local thermodynamic state in the layer. Stability and instability can therefore be ...