The browning of white fat has become a hot topic as it could help to lose weight and improve metabolic health. Therefore, this study aims explore the in vivo or thermogenesis effect 6-gingerol (6G), natural bioactive compound ginger, clarify underlying mechanism. results showed that 6G limited gain, improved cold tolerance, increased energy expenditure high-fat diet-induced obese mice. Moreover...

Background: It has been reported that sphingosine kinase (SK) 2 plays a role in maintaining metabolism and glucose homeostasis. However, the mechanism remains uncertain. Objectives: The present research aimed to further investigate effect of SK2 knockout on high-fat diet (HFD)-induced obesity metabolic regulation. Methods: Male SK2−/− wild-type (WT) control mice were challenged with HFD for 8 w...

Divergent selection for heat production/loss (kcal.kg-.75.d-1), measured in 9- to 11-wk-old male mice, was conducted for 15 generations. Heat loss was measured for 15 h on individual animals placed overnight in direct, gradient-layer calorimeters. Selection for high (MH) and low (ML) heat loss and unselected control (MC) occurred in each of three replicates for a total of nine unique lines. Rep...