Some Water-soluble Vitamins in the Sweat of Tropically Acclimatized European Men BY J. W. H. LUGG AND I?. P. ELLIS Vol. 8 (1954), no. I P. 75, Table I , heading to ninth column: For Thiamine (mg/Ioo ml.) read Thiamine (pg/Ioo ml.). P. 76, lines 41 and 42: For (range 0.095-0.140 mg/Ioo ml.; mean 0.123 mg/Ioo ml.) read (range o*og5-0.140 ,ug/Ioo ml.; mean 0.123 ,ug/Ioo ml.) P. 77, Summary, para. ...

Thiamine-deficient encephalopathy is characterized by morphologic lesions in the brainstem and less extensively in the cerebellum, but the early neurologic signs reverse rapidly and fully with thiamine, indicating a metabolic disorder. The suggested causal mechanisms of the encephalopathy involve two thiamine-dependent enzymes: (a) impairment of pyruvate decarboxylase activity with decreased ce...

The patient is a 7-year-old girl with a history of repaired gastroschisis and short gut syndrome. She presented with a 4-day history of progressive encephalopathy, truncal ataxia, and omnidirectional gaze-evoked nystagmus. Peripheral lactate was 7.1 mmol/L. Serum thiamine level was decreased (,5 nmol/L). Brain magnetic resonance with spectroscopy is shown in the figure. A clinical diagnosis of ...

determine the erythrocyte transketolase (ETK) activity or thiamine pyrophosphate (TPP) effect on admission, or thiamine excretion. Tanphaichitr et a13 state that thiamine excretion alone is not a good index of the state of thiamine nutrition in an individual subject. The absence of cardiac and central nervous system manifestations may be explained partially by the fact that the patient restrict...

Two cats were presented with vestibular signs and seizures. Both cats were diagnosed with thiamine deficiency. The transverse and dorsal T2-weighted magnetic resonance (MR) images revealed the presence of bilateral hyperintense lesions at specific nuclei of the midbrain, cerebellum, and brainstem. After thiamine supplementation, the clinical signs gradually improved. Repeated MR images taken 3 ...

A 21-year-old woman presented with coma after 5 days of fever, gait ataxia, and somnolence. Brain MRI showed lesions in medial thalami, caudate heads, and periaqueductal region (figure). Hyperlactatemia was present; serum thiamine levels were normal. Thiamine IM 600 mg daily led to complete recovery within 3 days. Sequencing analysis of thiamine transporter 2 (THTR2) gene revealed a base deleti...

INTRODUCTION Loading of thiamine prior to glucose administration during hypoglycemia to prevent Wernicke's encephalopathy is routine in the prehospital setting. To date no study has looked at the validity of this therapy. METHODS We evaluated a retrospective cohort of 242 patients who received intravenous glucose for hypoglycemia comparing those who received thiamine supplementation versus th...

The significance of subclinical thiamine deficiency in the elderly was determined by assessing response to thiamine supplementation in a randomized double-blind, placebo-controlled trial. Thirty-five of 222 people aged > or = 65 y had two concentrations of erythrocyte thiamine pyrophosphate (TPP) < 140 nmol/L 3 mo apart and 41 other people had the first, but not the second, TPP concentration be...

In the recent literature several chemical methods for the determination of thiamine are described. Some of these admittedly lack specificity (l-3). The determination of the blue fluorescence in ultraviolet light of thiochrome, one of the oxidation products of thiamine, has been most widely investigated (4-12). Its application to the quantitative determination of thiamine is complicated by simil...

OBJECTIVE This study examined the effects of thiamine and thiamine pyrophosphate on oxidative damage developing in association with hepatic injury caused by alcohol toxicity in rats and on hepatic injury markers. MATERIALS AND METHODS Four groups of rats were used; control, a group receiving thiamine+ethanol, a group receiving thiamine pyrophosphate+ethanol and a healthy group. The experiment...