Restricted dietary intake is common among children with behavioral issues. Here we report a case of a severely autistic child who presented initially with limp but who soon developed cough, tachypnea, hypoxia, and tachycardia. An echocardiogram revealed evidence of pulmonary hypertension (PH) with severely dilated right ventricle and elevated right-sided pressures. The etiology of his PH was un...

26 ABSTRACT Thiamine is an essential vitamin that plays an important role in cellular production of energy from ingested food and enhances normal neuronal actives. Deficiency of this vitamin leads to a very serious clinical condition known as delirium. Studies performed in the United States and other parts of the world have established the link between thiamine deficiency and delirium. This lit...

We investigated the effects of vitamin B1 deficiency on the meiosis maturation of oocytes. Female Crl:CD1 (ICR) mice were fed a 20% casein diet (control group) or a vitamin B1-free diet (test group). The vitamin B1 concentration in ovary was approximately 30% lower in the test group than in the control group. Oocyte meiosis was not affected by vitamin B1 deficiency when the deficiency was not a...

In continuing studies in this laboratory on the role of thiamine in nervous tissue we have recently accumulated some evidence to suggest that the neurophysiologically active form of the vitamin may be thiamine triphosphate (TTP) as opposed to the coenzyme form, thiamine pyrophosphate (thiamine-PP) (l-3). Since a specific enzyme exists in brain which catalyzes the hydrolysis of thiamine-PP (4), ...

The possibility of an interrelationship between vitamins of the B group was first suggested by clinical observations. Scandinavian authors (l-3) have reported that treatment of multiple deficiencies with thiamine alone precipitated the appearance of lesions characteristic of nicotinic acid deficiency, and Sydenstricker (4) encountered the enhancement of certain signs of deficiency in pellagrins...

Neuropathic pain after nerve injury is severe and intractable, and current drugs and nondrug therapies offer substantial pain relief to no more than half of affected patients. The present study investigated the analgesic roles of the B vitamins thiamine (B1), pyridoxine (B6) and cyanocobalamin (B12) in rats with neuropathic pain caused by spinal ganglia compression (CCD) or loose ligation of th...

The immediate relief of lightning pains in tabetics remains a problem. Though sedatives are still the commonest drugs prescribed, medical measures such as administration of vitamin B1, ephedrine, adrenaline, and insulin have been suggested on supposed etiological grounds, but have failed to meet with general approval. Surgical procedures, such as epidural injections, division of the nerve roots...

Abstract Background Gayet–Wernicke's encephalopathy (GWE) is a life-threatening neurological emergency caused by vitamin B1 deficiency. This rare complication, which may be reversible if managed promptly. However, any diagnostic or therapeutic delay exposes to the risk of serious sequelae. Although this pathology frequently occurs in chronic alcohol users, it can also occur situation severe und...