A series of novel 2-(substituted phenyl)-5-methyl-3-(phenylamino)-1,3-thiazolidin-4-ones (4a-g) were synthesized, structurally confirmed by elemental, IR, H NMR and MS spectral analysis. Further evaluated for their anti-HIV activity and cytotoxicity in MT-4 cells infected with wild-type HIV-1 strain IIIB and HIV-2 strain ROD in comparison with nevirapine (NVP), azidothymidine (AZT), dideoxycyti...

Condensation of 3-acetyl-8-ethoxycoumarin (3) with thiosemicarbazide gave ethylidenehydrazinecarbothioamide 5, which was transformed into the thiazolidin-4-one derivatives 6,7. Interaction of 3 with DMF/POCl(3) gave b-chloroacroline derivative 8. Treatment of 3 with malononitrile gave benzo[c]chromone and 2-aminobenzonitrile derivatives 9 and 10, respectively with respect to the reaction condit...

A novel series of 2-(3, 5-dimethyl-1-phenyl-1H-4-pyrazolyl)-3-(aryl/heteroaryl)-1, 3-thiazolidin-4-one derivatives 4a-h has been synthesized readily in one-pot from 3, 5-dimethyl-1-phenyl-1H-4-pyrazolecarbaldehyde (3), and characterized via IR, NMR, MS and elemental analyses. Further, these compounds were screened for antibacterial (MIC) activity against Bacillus subtilis, Staphylococcus aureus...

A convenient synthesis of novel bi/tricyclic azasugars fused thiazolidin-4-one and thiazinan-4-one by the one-pot tandem Staudinger/aza-Wittig/cyclization reaction under microwave radiation was demonstrated. The reactions were carried out with the azidosugar 1 and mercaptan acids via a key intermediate Schiff base and stereoselectively afforded the titled bi/tricyclic azasugars in good yield. A...

A series of novel 2-[(substituted phenyl/heteroaryl)imino]-3-phenyl-1,3-thiazolidin-4-ones (4a-g) were synthesized, structurally confirmed by elemental analysis, IR, H NMR, MS spectral analysis and further evaluated for their anti-HIV activity and cytotoxicity in MT-4 cell cultures infected with wild-type HIV-1 strain IIIB and HIV-2 strain ROD in comparison with azidothymidine (AZT) and dideoxy...