Scorpion (Buthus tamulus) venom was subjected to neutralization by treating the venom with various chemicals such as hydrochloric acid, sodium hydroxide, thiourea, formaldehyde, zinc sulphate, acetic acid and trichloroacetic acid. The venom was also subjected to heat treatment. The levels of total protein, free amino acids and protease activity in neutralized venom decreased significantly. The ...

A new series of potent potent aryl/alkylated (bis)urea- and (bis)thiourea polyamine analogues were synthesized and evaluated in vitro for their antiplasmodial activity. Altering the carbon backbone and terminal substituents increased the potency of analogues in the compound library 3-fold, with the most active compounds, 15 and 16, showing half-maximal inhibitory concentrations (IC50 values) of...

Mono-, di-, and triprotonation of thiourea (H2N)2CS, was studied by low-temperature 1H, 13C, and 15N NMR spectroscopy in superacidic systems. In FSO3H/SO2ClF at -80 °C, thiourea is monoprotonated exclusively at the sulfur atom giving rise to [(H2N)2CSH]. The addition of SbF5 to this system increases the acidity of the solution and results in the observation of the diprotonated species [H3NC(SH)...

The free radical scavengers, dimethyl sulfoxide (MezSO) and thiourea, were used to assess the role of free radicals in the production of intercalator-induced DNA breaks and cytotoxicity in mouse leukemia L1210 cells. Both agents decreased X-ray break production, and this decrease was comparable in magni tude to the degree of inhibition of X-ray-induced cell killing. By contrast, Me2SO increased...

Organic compounds containing thiourea function find many industrial, agricultural, pharmaceutical and analytical applications. Consequently, convenient, reliable, rugged and cost-effective methods for ensuring the quality of commercial products based on it are highly desirable. The case with which hydrogen peroxide in the presence of an excess of sodium hydroxide oxdatively desulphurise the thi...

The discovery of novel small molecules that function as antibacterial agents or cellular probes of biology is hindered by our limited understanding of bacterial physiology and our ability to assign mechanism of action. We previously employed a chemical genomic strategy to identify a novel small molecule, MAC13243, as a likely inhibitor of the bacterial lipoprotein targeting chaperone, LolA. Her...

CdS/MoS2, an extremely efficient photocatalyst, has been extensively used in hydrogen photoproduction and pollutant degradation. CdS/MoS2 can be synthesized by a facile one-step hydrothermal process. However, the effect of the sulfur source on the synthesis of CdS/MoS2via one-step hydrothermal methods has seldom been investigated. We report herein a series of one-step hydrothermal preparations ...

The structures of diphenyl [3-methyl-1-(3-phenylthioureido)butyl]phosphonate and diphenyl [2-methyl-1-(3-phenylthioureido)butyl]phosphonate, both C(24)H(27)N(2)O(3)PS, are reported. In both compounds, the thiourea moiety adopts a syn-syn conformation (i.e. the S-C-N-C torsion angles are synperiplanar), which enables N-H...O hydrogen bonds to be formed between centrosymmetrically related molecul...

Functionalized carbohydrate-centered glycoclusters formed the starting material for the synthesis of tagged oligosaccharide and glycoconjugate mimetics, which were obtained by thiourea-bridging, peptide coupling and in particular squaric diester-mediated coupling. The latter method could also be utilized to provide new multivalent glycoconjugates, which were tested for their anti-adhesive prope...

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