Cefixime is a third-generation cephalosporin antibiotic with poor solubility and permeability. The aim was to compared between Dry Grinding (DG) Liquid-Assisted (LAG) methods formed cocrystal of cefixime nicotinamide. Cocrystal prepared in 1:1 molar ratio characterizated by differential scanning calorimetry (DSC), fourier transform infra-red (FTIR), electron microscopy (SEM), x-ray diffraction ...