Various abnormalities of hemostasis have been described in obesity, mainly concerning increased levels of plasminogen activator inhibitor-1, but other abnormalities of coagulation and platelet activation have been reported as well. Circulating microparticles have also been observed in obese patients. These suggest that obesity would be a risk factor for venous thromboembolism (VTE). Analysis of...

Background and Purpose We investigated the changes of circadian blood pressure patterns after thromboembolic and hemodynamic brain infarction and evaluated the relation between circadian blood pressure variation, infarct location, and activation of the autonomic nervous system after thromboembolic stroke. Methods Repeated 24-hour blood pressure measurements were performed in 45 patients with pr...

Homocystinuria follows an autosomal recessive pattern and transpires due to Cystathionine beta-synthase enzyme deficiency. This condition is associated with thrombotic thromboembolic complications increase in homocysteine methionine levels the plasma urine. We present a case of Indian adolescent boy who presented us generalized tonic clinic seizure Broca's aphasia he was diagnosed as having hom...

Stroke in women may be considered as a distinct entity due to numerous differences compared with men, including specific epidemiological, etiological, and outcome features along unique pathophysiological mechanisms. is the second cause of death worldwide sex-specific causes stroke youger such pregnancy, post-partum period, oral contraception migraine. Substitutive hormone treatment older no mor...

Cardiovascular diseases (CVDs) are among the world’s widely affected disorders, including ischemia and stroke. Acute Myocardial (AMI) is a deadly disease caused by irreversible damage to left ventricular heart tissues. The thromboembolic plaque stops oxygen supply main blood vessels ventricles. During chronic inflammation, myocardial infarction free radicals stable myocardium, smooth muscles ce...

It was the objective of this study to obtain best estimates of the prevalence of anti-PF4/heparin antibodies in patients not suspected to have clinical heparin-induced thrombocytopenia (HIT) prior to undergoing cardiac surgery and to determine whether preoperative antibody status and antibody class is predictive of postoperative thromboembolic outcomes, non-thromboembolic outcomes, length of st...

Thromboembolic stroke appears to evolve in patients in a very complicated manner. The present study investigated the evolution of thromboembolic stroke in rats (n=9) using a 4.7-T MR imager. Under isoflurane anaesthesia, the rats received homologous blood clots into the right internal carotid artery. After thromboembolic stroke, lesion volume, which was defined and calculated, based on apparent...

OBJECTIVES Although several reports suggest an increased thromboembolic event rate, especially regarding strokes and TIAs at early age in patients with Fabry disease (FD), the risk for patients with FD to experience these events, the clinical relevance of additional risk factors including the concurrence of factor V Leiden (FVL), and the benefit of enzyme replacement therapy (ERT) regarding the...

BACKGROUND AND PURPOSE It is unknown what the optimal anticoagulant level is to prevent thromboembolic stroke in patients with left ventricular assist device (LVAD) support. We aimed to evaluate the relation between coagulation status and the occurrence of thromboembolic stroke in HeartMate-II LVAD assisted patients. METHODS Thirty-eight consecutive patients with a HeartMate-II LVAD were incl...