Journal of Thoracic Oncology ® • Volume 9, Number 9, Supplement 2, September 2014 Abstract: A universal and consistent stage classification system, which describes the anatomic extent of a cancer, provides a foundation for communication and collaboration. Thymic epithelial malignancies have seen little progress, in part because of the lack of an official system. The International Association fo...

Our previous study reported that the DNA methylation of growth hormone secretagogue receptor (GHSR) was significantly higher in thymoma or thymic carcinoma (TC) than normal tissue samples. Thymic epithelial tumors (TETs) with GHSR were associated worse prognosis those lower levels methylation. Diversified components ghrelin‑GHSR axis may exert opposing effects cancer ...

We investigate a case of nodular hyperplasia of the thymic epithelium which was incidentally, microscopically discovered. Macroscopically there was no sign of tumor and the thymus was surgically removed for the therapy of the clinical symptoms of the myasthenia gravis worsened in two years of evolution. Histological in a general appearance of an involuted thymic tissue, a small nodular epitheli...

Journal of Thoracic Oncology ® • Volume 9, Number 9, Supplement 2, September 2014 Abstract: A universal and consistent stage classification system, which describes the anatomic extent of a cancer, provides a foundation for communication and collaboration. Thymic epithelial malignancies have seen little progress, in part because of the lack of an official system. The International Association fo...

A variety of antigens that display a highly tissue-specific expression pattern have recently found to be also expressed in medullary thymic epithelial cells (mTEC). This unique feature of mTEC plays an important role in preventing hazardous autoimmune responses through thymic tolerization of T-cell subsets directed against autoantigens but could also limit the possibility of exploiting tumor-as...

Thymic epithelial cells (TECs) are the major components of the thymic microenvironment for T cell development. TECs are derived from thymic epithelial progenitors (TEPs). It has been reported that human ESCs (hESCs) can be directed to differentiate into TEPs in vitro. However, the efficiency for the differentiation is low. Furthermore, transplantation of hESC-TEPs in mice only resulted in a ver...

Four cases of an unusual type of thymic hyperplasia strongly resembling lymphoepithelial sialadenitis (LESA) of the salivary glands are described. The patients were 2 men and 2 women aged 37 to 53 years. On histologic examination, abundant lymphoid tissue with lymphoid follicles containing germinal centers and areas of plasma cell infiltration were seen. The epithelial component consisted of a ...

Transgenic mice expressing the E7 protein of HPV16 from the keratin 14 promoter demonstrate increasing thymic hypertrophy with age. This hypertrophy is associated with increased absolute numbers of all thymocyte types, and with increased cortical and medullary cellularity. In the thymic medulla, increased compartmentalization of the major thymic stromal cell types and expansion of thymic epithe...

Introduction: Thymoma is a rare benign tumor with a largely indolent growth pattern. Anterior mediastinal mass is the commonest clinical presentation. It is to be distinguished from invasive thymoma i.e. thymic carcinoma by the presence of cellular features of malignancy and a greater incidence of local invasion and embolic metastases. Case presentation: We report a case of thymoma in a 25 year...

Thymic epithelial cells (TEC) heterogeneity suggests the existence of functional subsets. Anti-cytokeratin (Anti-CK) monoclonal antibodies (MAb), markers of epithelial differentiation, have been used to detect TEC subsets in rodents and humans. These MAb revealed a different topography of CK-defined TEC subsets in mice and humans, leading us to carry out a comparative study of mammalian thymuse...