Methotrexate (MTX) inhibition of the growth of mouse or human leukemia cells in culture was partially prevented by either thymidine (dThd) or hypoxanthine. 5-Fluoro-2'-deoxyuridine (FdUrd) also decreased the growth-inhibitory potency of MTX in the presence of small concentrations of 5-formyltetrahydrofolate (citrovorum factor) and sufficient exogenous dThd to support the synthesis of thymidylat...

Cancer is one of the chronic diseases with a reasonably high increase at this time. One type cancer highest mortality rate colorectal cancer. Colorectal that occurs in colon and rectum. Based on GLOBOCAN data (2018), cases Indonesia reached 8.6% or 30,017 people were second most common cause death men third women. The development drugs to obtain better activity, lower toxicity, working more sel...