OBJECTIVE To review the epidemiological literature relevant to evaluating the risk of adverse effects on thyroid function associated with environmental perchlorate exposure. METHODS All studies investigating possible adverse effects of environmental perchlorate exposure on thyroid function in adults or in pregnant women and their newborns were critically evaluated. RESULTS There is no credi...

Thyroid incidentaloma is defined as a new identified thyroid lesion occasionally detected during imaging studies. Incidence of thyroid incidentalomas is relatively rare in patients with lymphoma. Because of high rate of malignancy, these lesions with high intensity focal 18 FDG uptake detected on positron emission tomography with computed tomography (PET/CT) should undergo to biopsy regardless ...

OBJECTIVE Thyroid findings or incidentalomas in (18)F-FDG PET/CT studies are relatively frequent, being its clinical significance subject of controversy. The aim of this study was to show our experience in the detection of thyroid incidentalomas by PET/CT studies as well as its follow up. MATERIAL AND METHODS A retrospective and descriptive review was conducted on patients who had thyroid inc...

Volume 95 No. 2 February 2012 CliniCal presentation A 34 year-old female patient was found on ultrasound to have multinodular goiter with a complex 1.3 cm thyroid nodule in the lower pole of the left thyroid lobe. Fine needle aspiration of this thyroid nodule revealed cytology that was highly suspicious for cystic papillary thyroid carcinoma. She underwent total thyroidectomy; surgical patholog...

Fertile White Leghorn chicken eggs were injected on the 10th day of incubation with 0, 1.50, or 2.00 p.p.m. Thimet and allowed to hatch. The following parameters were examined: hatchability, incidence of deformities, thyroid weight, thyroid histology, thyroid I uptake, and brain cholinesterase activity. As the Thimet dosage was increased, the hatchability decreased, and the incidence of deformi...

OBJECTIVE Thyroid cancer is the most common endocrine cancer. This review evaluates the established use of (18)F-FDG PET/CT in papillary, follicular, Hürthle cell, anaplastic, and medullary thyroid cancers. The significance of incidental diffuse and focal thyroid FDG uptake is discussed. The evolving value of non-FDG radiotracers, including (124)I, (18)F-dihydroxyphenylalanine, and (68)Ga somat...

• I ablation of remnant thyroid tissue following a total or near-total thyroidectomy for thyroid cancer is carried out in the hypothyroid state to increase endogenous TSH release and thus promote uptake of radioodine into the remaining thyroid tissue. Usually thyroid replacement therapy has to be withheld from patients for 3 to 6 weeks before ablation in order to achieve an adequate TSH level. ...

UNLABELLED In patients with progressive metastatic (or recurrent) differentiated thyroid carcinoma (DTC) who do not respond to radioiodine therapy or do not show uptake on radioiodine scintigraphy, treatment options are few. Because these tumors may express somatostatin receptors, peptide receptor radionuclide therapy might be effective. We evaluated the therapeutic efficacy of the radiolabeled...

Radioimmunoasaay is an accurate and direct method for assessing thyroxine (T4)-binding globulin concentrations. Because such techniques are costly, time consuming, and use radioactive materials, nonisotopic assays are often favored. Although it is an indirect measure of T4 binding protein CFBP) concentration, resin triiodothyronine uptake (RT3U) has been the most widely used test, to date, for ...

Radioiodide (RAI) therapy of thyroid cancer exploits the relatively selective ability of thyroid cells to transport and accumulate iodide. Iodide uptake requires expression of critical genes that are involved in various steps of thyroid hormone biosynthesis. ERK signaling, which is markedly increased in thyroid cancer cells driven by oncogenic BRAF, represses the genetic program that enables io...