CONTEXT We recently found that patients with X-linked hypophosphatemic rickets (XLH) have a muscle function deficit in the lower extremities. As muscle force and bone mass are usually closely related, we hypothesized that patients with XLH could also have a bone mass deficit in the lower extremities. OBJECTIVE The study objective was to assess the muscle-bone relationship in the lower extremi...

To enhance new bone formation for the treating of patients with osteopenia and osteoporosis, various mechanical loading regimens have been developed. Although a wide spectrum of loading frequencies is proposed in those regimens, a potential linkage between loading frequencies and locations of loading-induced bone formation is not well understood. In this study, we addressed a question: Does mec...

Women drastically loose bone during and after menopause leading to osteoporosis, a disease characterized by low bone mass increasing the risk of fractures with minor trauma. Existing therapies mainly reduce bone resorption, however, all existing drugs have severe side effects. Recently, the focus is to identify alternative medicines that can prevent and treat osteoporosis with minimal or no sid...

Background and purpose - Fracture healing involves different inflammatory cells, some of which are not part of the traditional bone field, such as B-cells and cytotoxic T-cells. We wanted to characterize bone healing by flow cytometry using 15 different inflammatory cell markers in a mouse model of metaphyseal injury, and incidentally discovered a previously unknown general skeletal reaction to...

The goal of this study was to examine age and secular trends in bone and blood lead levels of community-exposed men. Bone and blood lead levels were measured twice, with a 3-year interval between measurements, among participants in a longitudinal study of aging. Seventy subjects (mean age = 66 years, age range = 52-83 years) with repeated measurements of bone and blood lead levels were studied....

Recent reports have suggested that production of superoxide or other reactive oxygen species by activated osteoclasts may play a role in the complex process of bone resorption; however, the enzyme responsible for production of superoxide by osteoclasts has not been characterized. To determine if osteoclasts express NADPH-oxidase, a superoxide-generating enzyme found in phagocytic leukocytes, im...

CONTEXT Osteoporosis is often a presenting sign of celiac disease (CD). Whether skeletal fragility in CD is associated with microarchitectural abnormalities is not known. OBJECTIVE The objective of the study was to evaluate microarchitecture and biomechanical properties of bone in CD. DESIGN This was a case-control study. SETTING The study was conducted at a university hospital outpatient...

Purpose: The changes in the bone density of immature Sprague-Dawley (SD) rats whose sciatic nerve was cut were investigated to understand the patterns of bone density deterioration and to establish the rationale for preventive managements. Materials and methods: Eighteen six-day-old SD rats were randomly divided into the right sciatic neurectomy and sham-operation group. The trabecular bone den...

Broiler starter diets from three commercial feed mills (same company, different locations) were fed to day-old Hubbard Hi-Y broiler chicks along with a Control diet manufactured at Ohio State University. The analyzed calcium levels were as follows: Source 1, .76% ; Source 2, .97% ; Source 3, .81 % ; Control, .98%. Each of the diets was fed to 5 replicate pens of broiler chicks in Petersime batt...

This paper presents an X-ray diffraction method of measuring the residual stress/strain in bone tissue of rabbit's tibia. To derive the residual stress, bone powder of the diameter less than 40 micrometers was used as a control specimen at non-stressed state. From the X-ray measurements, it was clear that the distribution of residual stress existed in the bone tissue. The tensile residual stres...