BACKGROUND No/slow reflow gives rise to serious complications in STEMI patients undergoing PCI, and can lead to worse outcomes. Several measures are used to prevent no/slow reflow, including thrombus removal processes and intensive use of anticoagulant agents. Our study was designed to evaluate the efficacy and safety of thrombectomy and intracoronary administration of GPIIb/IIIa inhibitors in ...

CONTEXT Women who present with acute coronary syndromes (ACSs) have different characteristics than men. Reports have conflicted about whether different outcomes exist for women with use of a routine invasive management strategy. However, these studies were performed prior to the widespread use of platelet glycoprotein IIb/IIIa inhibitors and intracoronary stents. OBJECTIVE To determine sex di...

Patients with a rare bleeding disorder characterised by skin and mucosal bleeding – typical of thrombocytopenia – but with a normal platelet count, and later characterised by a defective aggregation to all agonists, described as Glanzmann thrombasthenia, have mutations in a platelet membrane glycoprotein (GP) called GP IIb/IIIa, also known as the integrin αIIbβ3 (1). Such discovery paved the ro...

This case report describes the management of a middle-aged hypertensive male patient who presented with acute inferior ST-segment elevation myocardial infarction accompanied with severe hyperkalemia. His coronary angiography revealed a thread like right coronary artery along its entire course and normal left coronary artery system with patent coronary stents in the left anterior descending and ...

Reagents and solutions Integrilin (eptifibatide, 0.75 mg/mL) was purchased from Millennium Pharmaceuticals Inc. (Cambridge, MA) and Aggrastat (tirofiban hydrochloride, 50 μg/mL) was from Medicure Pharma Inc. (Somerset, NJ). Gly-Pro-ArgPro (GPRP) peptide was purchased from Sigma (St. Louis, MO), human α-thrombin was from Haematologic Technologies Inc (Crossing, VT), A23187 was from Calbiochem (S...

BackgroundIntracranial artery dissection is an uncommon cause of acute ischemic stroke. Although stenting the dissected arterial segment a therapeutic option, associated antiplatelet regimen remains matter debate.ObjectivesTo evaluate efficacy and safety intracranial together with concomitant intravenous administration tirofiban to perform systematic review literature.Materials methodsA single-...