Endothelial cells (ECs) sense and respond to fluid flow regulate immune cell trafficking in all organs. Despite sharing the same mesodermal origin, ECs exhibit heterogeneous tissue-specific characteristics. Human pluripotent stem (hPSCs) can potentially be harnessed capture this heterogeneity further elucidate endothelium behavior satisfy need for increased accuracy breadth of disease models th...

Background: Mesenchymal stem cells (MSCs) are multipotent cells able to differentiating into a variety of mesenchymal tissues including osteoblasts, adipocytes and several other tissues. Objectives: Differentiation of MSCs into fibroblast cells in vitro is an attractive strategy to achieve fibroblast cell and use them for purposes such as regeneration medicine. The goal of this s...

Tissue specific transcription factors play important roles during cellular differentiation. To regulate cellular differentiation, we paid attention to tissue specific basic helix-loop-helix (bHLH) transcription factors. In this study, we tried to regulate expression of tissue specific transcription factor for induction of cellular differentiation. To regulate expression of transcription factor,...

objective(s): three-dimensional biomimetic scaffolds have widespread applications in biomedical tissue engineering due to similarity of their nanofibrous architecture to native extracellular matrix. co-culture system has stimulatory effect on chondrogenesis of adult mesenchymal stem cells. this work presents a co-culture strategy using human articular chondrons and adipose-derived stem cells (a...