Abstract Background Mesenchymal stem cells derived from human umbilical cord (hUC-MSCs) have immunomodulatory properties that are of interest to treat novel coronavirus disease 2019 (COVID-19). Leng et al. recently reported hUC-MSCs one donor negatively expressed Angiotensin-Converting Enzyme 2 (ACE2), a key protein for viral infection along with Transmembrane Serine Protease (TMPRSS2). The pur...

Use of normothermic ex vivo lung perfusion (EVLP) was adopted in clinical practice to assess the quality marginal donor lungs. Subnormothermic temperatures are use among other solid organs improve biochemical, and immunological parameters. In a rat EVLP model donation after circulatory death (DCD) donors, we tested effect four subnormothermic that could further organ preservation. Warm ischemic...

HISTOCOMPATIBILITY (HLA) typing is primarily used to match kidney donors with awaiting recipients. However many studies have been carried out to determine the frequency of the HLA antigens in various diseases. In this laboratory we have been requested to carry out such studies in several diseases, e.g. diabetes, ankylosing spondylitis, farmer's lung, Plummer-Vinson stricture and flax byssinosis...

The clinical use of human tissues is a therapeutic reality in many diseases, observing a spectacular increase in their demand in recent years. This has also generated an increase in the demand for donors which, in regarding to obtaining tissues, is not limited to brain death donors. Consequently, tissues obtained from cardiorespiratory arrest donors must be promoted in our hospitals. With this ...

In articular cartilage tissue engineering (ACTE) experimentation, the researchers have utilised cells and tissues sampled from human donor for research purposes. The may be harvested living donor’s discarded through a medical procedure, e.g. total knee replacement surgery. small pieces of sample taken are essential to study regeneration treating joint disease, i.e. osteoarthritis. However, proc...