The neurotrophin nerve growth factor (NGF) regulates neuronal growth, differentiation, and survival during development. However, the precursor of NGF, proNGF, is a potent apoptotic ligand for the p75 neurotrophin receptor (p75(NTR))-sortilin complex. The mechanisms that regulate cleavage of proNGF, therefore, are critical determinants of whether this factor promotes neuronal survival or death. ...

Introduction In order to assess long-term safety of radioactive iodine administration in treatment of thyrotoxicosis, we assessed concentrations of selected markers of risk cardiovascular disease, i.e. matrix metalloproteinase 2 (MMP-2), its main inhibitor TIMP-2, matrix metalloproteinase 9 (MMP-9), its main inhibitor TIMP-1, as well concentrations of anti-inflammatory adiponectin and pro-infla...

METHODS. Corneas of BALB/c mice were injured with NaOH, irrigated copiously with PBS, and treated topically with either T 4 or PBS twice daily. At various time points after injury (PI), corneas from the T 4versus the PBS-treated group were examined for polymorphonuclear leukocyte (PMN) infiltration, chemokine, and matrix metalloproteinase (MMP)/tissue inhibitor of metalloproteinase (TIMP) expre...

Tissue inhibitor of matrix metalloproteinase-1 deficient (TIMP-1(-/-)) mice and wild-type (TIMP-1(+/+)) controls were kept on a standard (SFD) or a high fat diet (HFD) for 15 weeks. At the time of sacrifice, TIMP-1(-/-) mice on HFD had a significantly lower body weight (29 +/- 1.5 versus 41 +/- 1.8 g, p <0.005), and significantly less subcutaneous (0.81 +/- 0.19 versus 1.78 +/- 0.21 g, p <0.05)...