نتایج جستجو برای: tlr
تعداد نتایج: 8542 فیلتر نتایج به سال:
BACKGROUND Chronic obstructive pulmonary disease (COPD) is characterised by pulmonary and systemic inflammation which flare-up during episodes of acute exacerbation (AECOPD). Given the role of Toll-like receptors (TLRs) in the induction of inflammatory responses we investigated the involvement of TLRs in COPD pathogenesis. METHODS The expression of TLR-2, TLR-4 and CD14 in monocytes was analy...
The Drosophila tolloid (tld) and tolloid related (tlr) gene products belong to a family of developmentally important proteases that includes Bone Morphogenetic Protein 1 (Bmp1). Tld is required early in Drosophila development for proper patterning of dorsal embryonic structures, whereas Tlr is required later during larval and pupal stages of development. The major function of Tld is to augment ...
BACKGROUND Female sex was reported to be associated with lower risk for midterm restenosis and repeat revascularization after bare-metal stent implantation. However, the influence of sex on very long-term outcomes after bare-metal stent implantation has not been yet reported. METHODS AND RESULTS Among the 9877 patients in the multicenter Coronary Revascularization Demonstrating Outcome study ...
Response, and Arteriosclerosis To the Editor: There is increasing evidence that Toll-like receptor (TLR)dependent signaling and cell activation is critically involved in the pathogenesis of arteriosclerosis. The article by M. Kazemi et al impressively demonstrates that Toll-like receptor agonists induce lipid accumulation and proteins involved in atherosclerotic plaque development such as adipo...
We have recently shown that Toll-like receptor (TLR) signaling exacerbates pancreatic fibro-inflammation and promotes carcinogenesis in mice. Paradoxically, inhibition of the TLR-MYD88 signaling pathway is pro-tumorigenic owing to the dendritic cell-mediated TH2-polarization of CD4+ T cells. TLR signaling appears to be central in pancreatic cancer-associated inflammation.
T regulatory (Treg) cells that suppress immune responses may limit the efficiency of cancer immunotherapy. Recent findings indicate that Toll-like receptors (TLR) directly regulate the suppressive activity of Treg cells. Linking TLR signaling to the functional control of Treg cells may offer new opportunities to improve the outcome of cancer immunotherapy by coadminstration of certain TLR ligands.
There is a paucity of data on the comparison drug-coated balloons (DCB) versus drug-eluting stents (DES) for femoropopliteal lesions. We conducted regression-based meta-analysis to compare DCB DES in peripheral arterial disease (PAD). An online literature search was MEDLINE (EMBASE and PubMed), Cochrane, Web Science using PRISMA strategy from inception till November 2022. Statistical analysis d...
The mammalian brain is composed of 20% oxygen. depletion in the level oxygen may lead to hypoxia, resulting neurological changes. Recent findings Toll-like receptors (TLR) such as TLR-2, 3, 4 and 8 nervous system showedneuroinflammation brain. activation TLR4 by both exogenous endogenous ligands leads various inflammatory diseases likeatherosclerosis, Crohn’s disease, ulcerative colitis, rheuma...
Pattern recognition receptors represent the first line of defense against invading pathogens. Herpes simplex virus (HSV) encodes multiple ligands detected by these receptors, yet persists in the majority of infected individuals indicating a breakdown in host defense against the virus. Here we identify a novel mechanism through which HSV immediate-early protein ICP0 inhibits TLR-dependent inflam...
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