Purpose:68Ga-labeled DOTA-4-amino-1-carboxymethyl-piperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 (68Ga-RM2) is a synthetic bombesin receptor antagonist that targets gastrin-releasing peptide receptors (GRPr). GRPr proteins are highly overexpressed in several human tumors, including prostate cancer. We present data from the use of 68Ga-RM2 in patients with biochemical recurrence (BCR) of p...

List-mode processing is an efficient way of dealing with the sparse nature of PET data sets, and is the processing method of choice for time-of-flight (ToF) PET. We present a novel method of computing line projection operations required for list-mode ordered subsets expectation maximization (OSEM) for fully 3-D PET image reconstruction on a graphics processing unit (GPU) using the compute unifi...

Today Time-of-Flight (TOF), in PET scanners, assumes a single, well-defined timing resolution for all events. However, recent BGO-Cherenkov detectors, combining prompt Cherenkov emission and the typical BGO scintillation, can sort events into multiple kernels, best described by Gaussian mixture models. The number of photons detected per event impacts directly detector time signal rise time, whi...

A number of techniques allow imaging of the cerebral blood flow (CBF). Flow-sensitive time-of –flight (TOF) magnetic resonance imaging (MRI) demonstrates good representation of the flow but the extracranial hemodynamics could be assessed by color duplex ultrasound of the carotid arteries. Computerized tomography (CT), Xenon enhanced or CT perfusion with iodinated contrast, singlephoton emission...