In order to evaluate the immunogenicity, safety, and tolerability of monovalent 2009 pandemic influenza A/H1N1 MF59-adjuvanted vaccine in patients with β-thalassemia major, 31 subjects (19 males; mean age 17.8±8.7 years) with β-thalassemia major and 28 age- and gender-matched healthy controls were enrolled. Four weeks after vaccination, seroconversion rates were about 80% and seroprotection rat...

Objective: To evaluate the effects of lactulose for bowel preparation prior to colonoscopy in adults. Methods: By searching literature pertaining RCT (randomized controlled trial) with adults up 10th July, 2021. The experimental group utilizes oral solution as choice while control uses standard solution. Literature selection and data extraction were completed independently by 2 researchers, inc...

Drugs that act on the calcitonin gene-related peptide (CGRP) pathway herald dawn of a new era in management migraine headaches. The blockade CGRP alleviates neural inflammation and has been associated with reduced pain sensitization. Zavegepant is third-generation drug first intranasal antagonist to be developed. This systematic review aims assess safety, efficacy, pharmacokinetics, tolerabilit...

To assess the efficacy and tolerability of topically applied low-concentration (less than 1%) capsaicin for treating chronic neuropathic pain in adults.

Purpose: The aim of this study was to assess the sex differences in enrollment into clinical trials for Dupuytren's disease (DD), treatment efficacy, and complications. Methods: Three databases were searched; Ovid MEDLINE, EMBASE, EBSCO CINAHL. Included studies on adult patients with DD. Exclusion criteria non-English other designs. Two independent reviewers completed abstract screening, full-t...

Background. The need to use BRAF and MEK inhibitors in the treatment of patients with metastatic and/or unresectable + melanoma certain clinical situations is beyond doubt nowadays. medical community more information about new combination targeted therapy approved Russia, further details on expected efficacy tolerability, potential differences from existing combinations.
 Aim. To present s...

Background: Acyclovir, a specific and selective inhibitor of replication of herpesviridae family, has well documented efficacy for speedy rash healing and decreasing pain of herpes zoster. Limited oral bioavailability of acyclovir requires frequent dosing. Valacyclovir is rapidly and almost completely converted to acyclovir in vivo and gives three to fivefold increase in acyclovir bioavailabili...

Garbutt JC, Kranzler HR, O’Malley SS, et al. Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial. JAMA 2005;293:1617–25. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ....

Title: Long-term safety, tolerability and pharmacokinetics of the highest available dose of paliperidone palmitate: a one-year open-label study in patients with schizophrenia Authors:

Background: The Neonatal Abstinence Syndrome (NAS) has been treated so far by various drugs, such as opioids and non-opioids. There is some concern about NAS babies who receive chemical drug treatment. Some researchers mentioned that shorter pharmacological treatment and less lengthy hospitalization are associated with severa...