AWARD NUMBER: W81XWH-13-1-0277 TITLE: A Novel Approach for Effectively Treating SCI Pain, Improving Opioid Efficacy, and Preventing Opioid-Induced Constipation: Key Role of Toll-Like Receptor 4 (TLR4) PRINCIPAL INVESTIGATOR: Dr. Linda Watkins CONTRACTING ORGANIZATION: Regents of the University of Colorado Boulder, CO 80303 REPORT DATE: October 2014 TYPE OF REPORT: Annual PREPARED FOR: U.S. Army...

BACKGROUND Signaling through the B-cell receptor appears to be a major contributor to the pathogenesis of chronic lymphocytic leukemia. Toll-like receptors bridge the innate and adaptive immune responses by acting as co-stimulatory signals for B cells. The available data on the expression of Toll-like receptors in chronic lymphocytic leukemia are limited and derive from small series of patients...

INTRODUCTION AND AIMS Toll-like receptor 4 and proinflammatory cytokines play a central role in the progression of nonalcoholic fatty liver disease. We investigated IL-1, IL-6 and TNFα production and toll-like receptor 4 in both--obese and lean patients with non-alcoholic fatty liver disease who met different sets of metabolic syndrome criteria and linked the results with the disease burden. ...

A walk W between two non-adjacent vertices in a graph G is called tolled if the first vertex of W is among vertices from W adjacent only to the second vertex ofW , and the last vertex ofW is among vertices fromW adjacent only to the second-last vertex of W . In the resulting interval convexity, a set S ⊂ V (G) is toll convex if for any two non-adjacent vertices x, y ∈ S any vertex in a tolled w...

Softwarebasierte Funktionalitäten gewinnen zunehmend an Bedeutung für moderne Automobile – ein Großteil der Innovationen wird von Elektronik und Software getrieben. Zahlreiche Sicherheitsund Komfortfunktionen werden durch Software ermöglicht. Automobile eingebettete Systeme bilden ein hochkomplexes heterogenes Netzwerk, bestehend aus bis zu 70 Steuergeräten. Die Beherrschung der Komplexität die...

With the rapid growth of highway traffic, congestion toll station has become a common phenomenon in peak hours. However, at serious impact on normal operation expressway. When queuing vehicles overflow station, queue leader will lose control, and main line be seriously disturbed. This paper analyzes causes stations, studies characteristics different channels traffic flow, then establishes flow ...