Aims of Study It is well known that the activation of the sympathetic nervous system contributes to urine storage by relaxing the detrusor via activation of beta-adrenoceptors (beta-ARs). It has been demonstrated that the relaxation of human detrusor, including the neurogenic detrusor, is mediated mainly via beta3-ARs [1-3]. However, the beta3-AR agonists previously used, such as BRL37344A, CL3...
