With exponential increase in the number of cases of cancers worldwide in recent past, it is imperative to enhance our understanding about the etiologic and risk factors associated with this seriously morbid condition. Increasing attention has been focussed on chronic infections and inflammatory diseases, implicating a role in carcinogenesis, particularly in developing countries. Periodontal dis...

BACKGROUND Orodental diseases include several clinically and genetically heterogeneous disorders that can present in isolation or as part of a genetic syndrome. Due to the vast number of genes implicated in these disorders, establishing a molecular diagnosis can be challenging. We aimed to develop a targeted next-generation sequencing (NGS) assay to diagnose mutations and potentially identify n...

Aging per se has a small effect on oral tissues and functions, and most changes are secondary to extrinsic factors. The most common oral diseases in the elderly are increased tooth loss due to periodontal disease and dental caries, and oral precancer/cancer. There are many general, medical and socioeconomic factors related to dental disease (ie, disease, medications, cost, educational backgroun...

Data dealing with successful or unsuccessful acrylic tooth implants have accumulated gradually during the past 20 years. Flohr' studied plastic material as a possible substitute for natural teeth by placing screw-type acrylic roots into surgically created alveolar sockets. He reported that normal connective tissue formed against the acrylic, and only minimal infiltration occurred. Hodosh, et al...

Poor oral health and tooth loss have been proposed as possible risk factors for some chronic diseases, including gastric cancer. However, a small number of studies have tested these associations. We conducted a case-control study in Golestan Province, Iran, that enrolled 309 cases diagnosed with gastric adenocarcinoma (118 noncardia, 161 cardia, and 30 mixed-locations) and 613 sex, age, and nei...

In recent years, substantial progress has been made regarding the molecular etiology of human structural tooth diseases that alter dentin matrix formation. These diseases have been classified into two major groups with subtypes: dentin dysplasia (DD) types I and II and dentinogenesis imperfecta (DGI) types I-III. Genetic linkage studies have identified the critical loci for DD-II, DGI-II, and D...

At the "International Workshop for a Classification of Periodontal Diseases and Conditions" in 1999, the classification of periodontal diseases was revised (Armitage 1999). The various types of periodontitis were divided into three main categories (chronic, aggressive, and necrotizing periodontitis) as well as into a periodontal a manifestation of systemic diseases. This article provides a syno...