OBJECTIVE To compare the safety and efficacy of 1% SDZ ASM 981 cream and a matching placebo cream in the treatment of patients with moderate atopic dermatitis. DESIGN A randomized, double-blind, placebo-controlled, right-and-left comparison study. SETTING Academic referral center. PATIENTS Thirty-four adult patients with moderate atopic dermatitis. INTERVENTION Topical 1% SDZ ASM 981 cr...

Topical anesthetics act on the peripheral nerves and reduce the sensation of pain at the site of application. In dentistry, they are used to control local pain caused by needling, placement of orthodontic bands, the vomiting reflex, oral mucositis, and rubber-dam clamp placement. Traditional topical anesthetics contain lidocaine or benzocaine as active ingredients and are used in the form of so...

The last 2 decades more and more attention has been given to topical analgesia. Peripheral nerves in the epidermis are influenced by topical analgesics with the aim to reduce neuropathic pain. Systemic side effects are rare, because the purpose of topical analgesics is not to penetrate deeper than the epidermis. Thus topical analgesics are particularly beneficial in the treatment of geriatric p...

Abstract. A study on physicochemical characteristics of Ceiba petandra and Lannea kerstingii stem bark extracts cream being developed for the treatment of topical dermatophytic infections has been carried out to assure safe, effectiveness and stability during storage and usage. The stem barks of Ceiba petandra and Lannea kerstingii were extracted with methanol and ethyl acetate respectively. Th...

Basal cell carcinoma and actinic keratosis are frequent neoplasms. Topical treatments include the recently approved imiquimod cream. We describe here the case of a 68-year-old man with multiple actinic keratosis on the forehead, upper trunk and on the left cheek. In addition, an exulcerated basal cell carcinoma was observed. The patient was advised only to treat lesions on the forehead with imi...

BACKGROUND Leishmania is a unicellular protozoan parasite that produces several human diseases, ranging from localized self-healing cutaneous lesions to deadly visceral infections. OBJECTIVE The effect of allicin on the growth of Leishmania major (L. major) promastigotes was evaluated under in vitro conditions. Moreover, the efficacy of a topical allicin cream was examined in BALB/c (Bagg alb...

BACKGROUND Scabies is an ectoparasitic infection, which occurs because of direct skin-to skin contact. The ideal treatment modality is still unclear and further research on this topic is warranted. The aim of the study was to compare the efficacy and safety of the topical scabicides: permethrin, crotamiton and sulfur ointment. METHODS Fifty four patients with diagnosed scabies were randomly d...