Evidence-Based Answer No differences in efficacy for pain and other symptoms of osteoarthritis have been found in direct comparisons of nonselective, selective, and partially selective nonsteroidal anti-inflammatory drugs (NSAIDs). Acetaminophen is modestly inferior to NSAIDs for pain relief. Among topical formulations, diclofenac is comparable to oral NSAIDs for treating localized osteoarthrit...

objective: to detect whether the preoperative combined administration of rectal diclofenac and paracetamol is superior to placebo or rectal diclofenac alone for pain after abdominal hysterectomy. materials and methods: ninety female patients (american society of anesthesiologists (asa) physical status i-ii), scheduled for abdominal hysterectomy were recruited to this double blind trial and were...

Case  Description- A  3-month-old  female  intact  Boxer  dog  was  presented  to  the  Veterinary  Hospital  of  Shahid Bahonar  University  of  Kerman  with  a  complaint  epiphora,  photophobia  and  corneal  opacity  of  both  eyes.  Clinical Findings-  Ophthalmic  examination  revealed  mild  blepharospasm  and  mucoid  discharge  of  both  eyes,  with  severe  bilateral  chemosis  and  c...

purpose: to evaluate the efficacy of pretreatment with diclofenac sodium 1% eye drop for prevention of post-cataract surgery ocular inflammation. methods: a double blind clinical trial was performed on 111 patients who were scheduled for phacoemulsification and intraocular lens implantation (pe+iol) at feiz hospital, isfahan-iran. cases with traumatic cataract and complicated surgery were exclu...

The present work was performed with the objective of novel topical formulation development poorly water-soluble drug Diclofenac diethylamine by loading drug-containing nanosponge into formulation. nanosponges are polymeric nanoparticles that entrap drug. drug-loaded has different absorption characteristics in comparison to pure delivery system. Methods: first loaded ethylcellulose using emulsio...

Diclofenac is a widely used analgesic drug that can cause serious adverse drug reactions. We used Saccharomyces cerevisiae as a model eukaryote with which to elucidate the molecular mechanisms of diclofenac toxicity and resistance. Although most yeast cells died during the initial diclofenac treatment, some survived and started growing again. Microarray analysis of the adapted cells identified ...

BACKGROUND Patients with painful knee osteoarthritis (OA) demonstrate hyperalgesia and altered pain-modulatory responses. While some prior work has demonstrated cross-sectional associations between laboratory and clinical pain measures, it is unknown whether individual variability in quantitative sensory testing (QST) responses at baseline can prospectively predict analgesic treatment responses...