Whole genome duplications, or tetraploidies, are an important source of increased gene content. Following whole genome duplication, duplicate copies of many genes are lost from the genome. This loss of genes is biased both in the classes of genes deleted and the subgenome from which they are lost. Many or all classes are genes preferentially retained as duplicate copies are engaged in dose sens...

Methods Mrs. E.F a 30 years old woman, was followed up, since 2003, for a lupus erythematous chronicus. In 2010, she presented a painful cheilitis of the upper lip that gradually increases in volume. Clinical examination showed a scaly macrocheilitis, the rest of the clinical examination was within normal limits. The labial biopsy showed a dyskeratotic hyperkeratosis, keratotic plugs, a pseudo-...

OBJECTIVE To compare the inverse planning optimization based on total dose constraints versus conventional treatment plan (point A planning method) for cervical carcinoma, and evaluate the benefit of CT-based image-guided brachytherapy. METHODS We prospectively analyzed data of 10 consecutive patients with cervical cancer treated with external beam radiotherapy to the whole pelvis (45 Gy in 2...

BACKGROUND Many factors contribute to the high variability of doses delivered to the lungs of patients using metered dose inhalers (MDIs). Relatively little attention has been paid to the contribution to this variability of the way in which the MDI is handled before the inhalation manoeuvre. Instruction leaflets often recommend procedures at odds with those used for in vitro testing of the devi...

SUMMARY 1-Methyl-l-nitrosourea (MNU), the active moiety of the Streptozotocin molecule, produces a dose-related depression of nicotinamide adenine dinucleotide (NAD) concentrations in mouse liver and L1210 ascities, similar to that produced by the latter compound. There was early increase in liver NAD glycohydrolase activity, but no significant change in NAD pyrophosphorylase. While pretreatmen...

Erythropoietin combined with parenteral iron sucrose therapy is an alternative to blood transfusion in anemic patients. It was shown to be effective in surgical patients in several previous studies when used in conjunction with other methods. However, there are no guidelines about safety limits in dosage amounts or intervals. In this study, we report a case of significant postoperative hemorrha...

Rats given 4 mg. fluoride/kg./day for eight days excreted more calcium and phosphorus and retained less than the controls. In bone ash from rats given different fluoride doses for 40 days the calcium and phosphorus were maximal after a total dose of about 250 ,tg. fluoride/rat, but fell to subnormal levels after higher doses. The calcium and phosphorus levels in bone ash from rats given 750 pg....

We have studied the plasma and peripheral leukocyte pharmacokinetics of mitoxantrone associated, in a high-dose regimen, with cyclophosphamide, carmustine, and etoposide in patients with refractory lymphoma undergoing autologous bone marrow transplantation. Nineteen patients with refractory lymphoma were involved in a clinical trial with escalated doses (15-90 mg/m2) of mitoxantrone administere...