The aim of this experiment was to clarify the contribution of the alpha-tocopherol transfer activity of lipoprotein lipase (LPL) to vitamin E transport to tissues in vivo. We studied the effect of Triton WR1339, which prevents the catabolism of triacylglycerol-rich lipoproteins by LPL on vitamin E distribution in rats. Vitamin E-deficient rats fed a vitamin E-free diet for 4 wk were injected wi...

Although vitamin E has been known as an essential nutrient for reproduction since 1922, we are far from understanding the mechanisms of its physiological functions. Vitamin E is the term for a group of tocopherols and tocotrienols, of which alpha-tocopherol has the highest biological activity. Due to the potent antioxidant properties of tocopherols, the impact of alpha-tocopherol in the prevent...

An HPLC method for determination of αand γ-tocopherol in rat blood has been optimized and validated. The optimum means of separation and analysis of tocopherol homologs were selected on the basis of procedures found in the literature; documentary evidence is presented which shows precision and accuracy were satisfactory. Spectrofluorimetric detection was performed after separation on a Separon ...

A novel metabolite of d-&tocopherol was isolated from the urine of rats given d-3,4-[sH2]-6-tocopherol intravenously. The metabolite was collected from the urine of rats given d-&tocopherol in the same manner as that of the labeled compound. It was found that the metabolites consisted of sulfate conjugates. The portion of the major metabolite released with sulfatase was determined to be 2,8-dim...

During investigations of new sources of higher plant lipids, seed fatty acid compositions and the tocopherol contents of some Isatis sp. (Isatis cappadocica subsp. steveniana, I. kotschyana, I. candolleana, I. spectabilis, I. glauca subsp. glauca and I. kozlowskyi) (Brassicaceae) were investigated by using GC and HPLC system. Some of the species are endemic to Turkey. All the Isatis species sho...

Antioxidant micronutrients may have chemopreventive effects. The authors examined the associations between prediagnostic blood levels of micronutrients and prostate cancer risk in two nested case-control studies of 9,804 and 10,456 male residents of Washington County, Maryland, who donated blood in 1974 (CLUE I) and 1989 (CLUE II), respectively. Until 1996, 182 men for whom adequate serum remai...

The nutritional composition of the edible seaweeds Durvillaea antarctica (frond and stem) and dried Ulva lactuca was determined, including the soluble (SDF), insoluble (IDF) and total (TDF) dietary fiber content, amino acid and fatty acid profiles along with tocopherols and tocotrienols (pro-vitamin E). Results show that U. lactuca contained 60.5 ± 1.5%, and D. antarctica frond and stem 71.4 ± ...

OBJECTIVE To determine the effect of ascorbic acid and alpha-tocopherol on oxidative stress and bone mineral density (BMD) in elderly people. DESIGN A double-blind, controlled clinical assay was carried out in a sample of 90 elderly subjects divided into three age-paired random groups with 30 subjects in each group. Group Tx0 received placebo, group Tx1 received 500 mg of ascorbic acid and 40...

AIM In the present study, we aimed to assess serum concentrations of zinc (Zn), copper (Cu), iron (Fe), cadmium (Cd), lead (Pb), manganese (Mn), vitamins A (retinol), D (cholecalciferol) and E (α-tocopherol) in patients with coronary artery disease (CAD) and to compare with healthy controls. METHODS A total of 30 CAD patients and 20 healthy subjects were included in this study. Atomic absorpt...