Toxic Epidermal Necrolysis is a rare dermatological condition with high mortality and serious consequences on its survivors. Despite having been first described in 1956, pathophysiology remains uncertain, mainly regarding mechanisms, although it seems that certain apoptosis pathways are pivotal starting keratinocytes’ activating T cells, especially those mediated by tumour necrosis factor, Fas-...

Epidermal nevi are hamartomas that are characterized by hyperplasia of the epidermis and adnexal structures, and may be associated with serious disfiguration. Germline mutations in the FGFR3 gene have found to be the etiology of epidermal nevus. Patients often seek treatment from dermatologic surgeons but even an alert dentist can help to diagnose the lesion from its clinical appearance. Variou...

This is the first case report to describe a 44-year-old woman with a history of advanced hepatocellular carcinoma who developed toxic epidermal necrolysis (TEN) clinically after taking 400 mg sorafenib (Nexavar®, BAY 43-9006) and tosufloxacin orally once per day. Both sorafenib and tosufloxacin were eventually discontinued, and the TEN resolved with corticosteroids and supportive treatment. Cli...

serious cases of recalcitrant molluscum contagiosum when other therapeutic choices have failed. The resolution of the lesions in our patient suggests that further studies are necessary to demonstrate the utility of intravenous cidofovir in immunodepressed patients and those with extensive lesions. However, Scolaro and Gordon (6) have recently described a promising alternative to the medical tre...