THE description of the microscopic structure of individual trabecular fibres given by Salzmann (1912) has been accepted for many years, and it is only as a result of recent electron microscopic studies that his classical concepts have had to be modified. The principle modification concerns the finer structure of the "clear" zone which lies beneath the trabecular endothelium and surrounds the ce...

PURPOSE To determine whether soluble CD44 (sCD44), a likely biomarker of primary open-angle glaucoma (POAG), is internalized in cultured human trabecular meshwork (TM) cells and trafficked to mitochondria. METHODS In vitro, 32-kD sCD44 was isolated from human sera, biotinylated, and dephosphorylated. TM cells were incubated for 1 hour at 4°C with biotinylated albumin (b-albumin), biotin-label...

The anatomic localization of the glucose transport protein in the eyes of rats, rabbits, baboons, marmosets, and humans with [3H]cytochalasin B using in vitro autoradiography showed high densities of glucose carrier densities. These densities were seen in the ciliary body, especially ciliary processes, iris, retina, and in some species, the trabecular meshwork and lens. In the lens, specific [3...

Conventional aqueous outflow pathway – Comprised of the trabecular meshwork, the juxtacanalicular connective tissue, the endothelial lining of Schlemm’s canal, Schlemm’s canal itself, the collecting channels, and aqueous veins. Flow resistance – The flow resistance (R=DP/Q) of a tissue is the ratio between the pressure drop across that tissue (DP) and the flow rate generated by that pressure dr...

A two-phase steady-state model for the percolation of aqueous humor through the trabecular meshwork (TM) in eye has been developed. The model treats the meshwork as an annular porous cylinder comprised of two concentric rings that represent the uveal-corneoscleral meshwork and juxtacanalicular meshwork. Both the rings are assumed to be made up of homogeneous, isotropic, viscoelastic material sw...