Context: Software Process Improvement initiatives have been around for many years with the growing globalisation of software development is making them increasingly important. Objective: The objective of this exploratory research is to gain an in-depth understanding of barriers that can undermine SPI, in the context of Global Software Development, from the perspective of software development pr...

When starting the software process improvement (SPI) journey, there are many SPI standards to select from. Selecting good SPI standards can be a technical problem, from a software engineering point of view, but it can also be a political problem, some standards fitting more with internal political agendas than others. As it is well-known that SPI without management commitment can have disastrou...

Overexpression of the transcription factor Spi-1/PU.1 in mice leads to acute erythroleukemia characterized by a differentiation block at the proerythroblastic stage. In this study, we made use of a new cellular system allowing us to reach graded expression of Spi-1 in preleukemic cells to dissect mechanisms of Spi-1/ PU-1 in erythroleukemogenesis. This system is based on conditional production ...

Previously it was shown that the Ets proteins, PU.1 and Spi-B, exhibit functional redundancy in B lymphocytes. To investigate the possibility that PU.1 or Spi-B or both share overlapping roles with Ets-1 or Elf-1, PU.1(+/-)Ets-1(-/-), PU.1(+/-)Elf-1(-/-), and Spi-B(-/-)Ets-1(-/-) animals were generated. No blood cell defects were observed in these animals except those previously reported for Et...

Acute leukemias are characterized by deregulation of transcriptional networks that control the lineage specificity of gene expression. The aberrant overexpression of the Spi-1/PU.1 transcription factor leads to erythroleukemia. To determine how Spi-1 mechanistically influences the transcriptional program, we combined a ChIP-seq analysis with transcriptional profiling in cells from an erythroleu...

background: emulsions are thermodynamically unstable systems that can be kinetically stable by adding substances known as emulsifiers and/or thickening agents. by respect to the functional properties of gum tragacanth (gt), and its breakage probability during irradiation treatment, the major aim of this study was to investigate the stability of oil in water emulsion in the presence of different...

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The ETS protein Spi-1/Pu.1 plays a pivotal and widespread role throughout hematopoiesis in many species. This study describes the identification, characterization, and functional analysis of a new zebrafish spi transcription factor spi-1– like (spi-1l) that is expressed in primitive myeloid cells, erythro-myelo progenitor cells, and in the adult kidney. Spi-1l functions genetically downstream o...

In order to define a modern approach for Software Process Improvement (SPI), the SPI Manifesto was developed, discussed, and finalized at the 16 EuroSPI Conference in 2009 in Alcala, Spain. The common understanding gained during the discussion and usage of the manifesto formed a nucleus from which the new ISO/IEC 33014[ISO01] was derived. In parallel to the development of the SPI Manifesto, the...