OBJECT Chronic subdural hematoma (CSDH) is a common condition after head trauma. It can often be successfully treated surgically by inserting a bur hole and draining the liquefied hematoma. However, to the best of the authors' knowledge, for nonemergency cases not requiring surgery, no reports have indicated the best approach for preventing hematoma enlargement or resolving it completely. The a...

Cardiopulmonary bypass is frequently associated with excessive blood loss. Platelet dysfunction is the main cause of non-surgical bleeding after open-heart surgery. We randomized 65 patients in a double-blind fashion to receive tranexamic acid or placebo in order to determine whether antifibrinolytic therapy reduces chest tube drainage. The tranexamic acid group received an intravenous loading ...

Aim: Topical Tranexamic acid (TXA) application provides maximum concentration of TXA at the bleeding site and avoids potential systemic effects. A number of blinded randomized control trials (RCT) have been published proving its safety and effectiveness. We hypothesised that in a person undergoing total knee replacement, if TXA was used topically on one side, it would reduce blood loss compared...

Background and Aims: Tranexamic acid has been used to decrease blood loss volumes and the subsequent need for blood transfusion in the orthopedic, spinal and cardiac surgeries. Methods: In this prospective controlled randomized clinical trial study, 24 candidates for orthognathic surgeries received tranexamic acid (20 mg/kg) intravenously just before the surgery while matched control patients r...

BACKGROUND Antifibrinolytics reduce death from bleeding in trauma and post-partum haemorrhage. We examined the effect of treatment delay on the effectiveness of antifibrinolytics. METHODS We did an individual patient-level data meta-analysis of randomised trials done with more than 1000 patients that assessed antifibrinolytics in acute severe bleeding. We identified trials done between Jan 1,...

Tranexamic acid (TA) is an antifibrinolytic agent which reduces bleeding following certain surgical procedures. The present study was performed on 56 patients, scheduled for elective endoscopic sinus surgery under general anesthesia, to examine the effects of topical TA on providing a bloodless surgical field and evaluate the bleeding volume. The study comprised 26 patients who received topical...

Background and Aims: Tranexamic acid has been used to decrease blood loss volumes and the subsequent need for blood transfusion in the orthopedic, spinal and cardiac surgeries. Methods: In this prospective controlled randomized clinical trial study, 24 candidates for orthognathic surgeries received tranexamic acid (20 mg/kg) intravenously just before the surge...