An efficient and facile green synthesis of chalcone derivatives 1a-d was achieved by treatment aromatic aldehydes with 2-acetylthiophene in the presence choline chloride-urea mixture as a deep eutectic solvent. Chalcone 1a used reactive key precursor to design series bio-active heterocycles such pyrimidine, pyrazoline, pyridine, pyridopyrimidine naphthyridine. The Structural formula were confir...

In the title chalcone derivative, C(17)H(15)BrO, the dihedral angle between the two benzene rings is 48.13 (4)°. In the crystal, a short Br⋯Br contact of 3.5052 (10) Å occurs.

A series of novel chalcone-1,2,3-triazole-azole hybrids were designed, synthesized and evaluated for their antiproliferative activity against three selected cancer cell lines (SK-N-SH, EC-109 and MGC-803). Most of the synthesized compounds exhibited moderate to good activity against all the cancer cell lines selected. Particularly, compound I-21 showed the most excellent antiproliferative activ...

A chalcone was prepared by the reaction of terephthalaldehyde with 3-acetyl-2,5-dimethylthiophene. Treatment of this chalcone with thiosemicarbazide/phenyl hydrazine/guanidine hydrochloride/thiourea afforded the corresponding pyrazoline, pyrazole, and pyrimidine in good yields. All the new compounds have been characterized by IR, 1H-NMR, 13C-NMR, GC-MS and elemental analyses. The anti-bacterial...

With the aim of finding new chemical entities based on coumarin and chalcone scaffolds, new hybrid compounds 2-5 were designed and synthesized. The trypanocidal activity of these compounds was tested against the epimastigote, trypomastigote and amastigote stages of the Trypanosoma cruzi parasite. Cytotoxicity assays were also performed in RAW 264.7 and VERO cells. Compound 5 presented the highe...

Herein we present a photoreactive chalcone moiety that can be synthesized at scale of several grams with ease, and efficiently undergo [2 + 2] photocycloaddition light close to 500 nm as determined by an action plot.

Many isoprenylated ̄avonoids have been isolated from the mulberry tree and related plants (Moraceae). Among them, kuwanons G (1) and H (2) were the ®rst isolation of the active substance exhibiting the hypotensive effect from the Japanese Morus root bark. These compounds are considered to be formed through an enzymatic Diels±Alder reaction of a chalcone (3) and dehydrokuwanon C (4) or its equiv...

Sixteen antimalarial alkoxylated and hydroxylated chalcones were tested for their ability to inhibit recombinant plasmepsin II in vitro. The best inhibitory compounds had either a chloro or dimethylamino group at the 4-position of phenyl ring A in the chalcone template. Combination of the chalcones with chloroquine showed additivity or mild antagonism of Plasmodium falciparum K1 growth in culture.

Cervical cancer is the second leading cause of death in women. Many treatments currently provide toxic effects on normal cells. Therefore, alternative treatment using chalcone derivatives has potent anticancer properties that can help reduce side effects. Chalcone with halogen and methoxy groups ring B potentially inhibit This research aimed to synthesize halogen-substituted by a green chemistr...