introduction cellular processes can be controlled by induction or repression of gene expression by introduction of exogenous genes and rna interference (rnai), respectively. however, the use of recently-developed specific dna-binding transcription factors offer various advantages when compared to the exogenous gene introduction and rnai for up or down regulation of gene expression. sox2 gene en...

A major problem for neuroscientists and clinicians is why the central nervous system shows ineffective regeneration after injury. Injured peripheral nerve fibers reform their connections, whereas those in injured spinal cord never re-grow. Insights into the mechanisms for repair and restoration of function after spinal cord injury have been obtained by experiments showing that injured nerve cel...

Three different experiments were conducted to study the effect of dietary astaxanthin on the immune response, resistance to white spot syndrome virus (WSSV) and transcription of antioxidant enzyme genes in Pacific white shrimp Litopenaeus vannamei. Each experiment included one triplicate treatment group (fed with 80 mg/kg astaxanthin supplemented diet) and one triplicate control group (fed with...

differentiation is an epigenetic process which is installed by changes of transcriptional programs over successive cellular divisions. a number of studies have reported the effects of biochemical modifications of chromatin (dna and chromatin proteins) on the regulation of transcription. although, these studies are able to explain how transcription of a given gene is regulated (toward activation...

objective(s): the janus kinase-signal transducers and activators of transcription signaling pathway (jak/stat pathway) play an important role in proliferation of breast cancer cells. previous data showed that inhibition of stat3 suppresses the growth of breast cancer cells, but the associated mechanisms are not well understood. this study aims to investigate the effect and associated mechanisms...