Blood transfusion history dates back about 200 years. The credit of first successful human to human blood transfusion goes to Dr. James Blundell, an obstetrician, who successfully transfused 8 oz (227 ml) of blood to a patient of postpartum hemorrhage in 1818 (Mahmud, 2009). In developing countries, the prevalence of transfusiontransmitted disease is much higher and far from attaining a “zero r...

Serum and liver tissues from hepatitis B surface antigen-negative/anti-hepatitis C virus (HCV)-negative (non-B, non-C) hepatocellular carcinoma (HCC) patients in Japan were examined for the presence of hepatitis B virus (HBV), HCV, and TT virus (TTV) by polymerase chain reaction. The studies evaluated the contribution of these viruses to pathogenesis of HCC. HBV DNA was detected in the sera of ...

In sub-Saharan Africa, transfusion-transmitted human immunodeficiency virus (HIV) infection persists, particularly among women and children, who receive most blood transfusions. Providing technical and financial assistance to national blood transfusion services to increase the adequacy of blood collections and to prevent transfusion-transmitted HIV infection continues to be a priority under the...

Testing of the DNA of TT virus (TTV) was done with serum samples obtained from 191 persons working in a public hospital of the city of Rio de Janeiro, Brazil. TTV DNA was detected by PCR in the sera of 125 (65.4%) individuals. PCR products were cloned, and sequences with a length of 159 bases surrounding the TATA signal region were determined for 100 clones derived from 31 individuals. One clon...

Molecular Detection Method for All Known Genotypes of TT Virus (TTV) and TTV-Like Viruses in Thalassemia Patients and Healthy Individuals Yu-Wen Hu,* Moslih I. Al-Moslih, Mahmoud Talib Al Ali, Shabnam Rahimi Khameneh, Heather Perkins, Francisco Diaz-Mitoma, Jean Nicholas Roy, Samra Uzicanin, and Earl G. Brown Canadian Blood Services, 1800 Alta Vista Drive, Ottawa, Ontario, Canada K1G 4J5; Depar...

A novel single stranded DNA virus, TT virus, associated with posttransfusion hepatitis was identified. The impact of the virus on development of chronic liver diseases and the susceptibility of the virus to interferon therapy has not been investigated. We retrospectively analyzed blood samples from 16 patients infected with both hepatitis C virus and TT virus who were treated by interferon. TT ...

Transfusion of blood and blood preparations is indispensible in modern medicine, and the processes of delivering a transfusion to a patient provide additional opportunity for risk, despite the remarkable progress. A spectrum of blood-borne infectious agents is transmitted through transfusion of infected blood donated by apparently healthy and asymptomatic blood donors. The diversity of infectio...

OBJECTIVE To assess the prevalence of TT virus (TMV) infection in a series of patients with chronic hepatitis C virus (HCV) infection, with or without benign (mixed cryoglobulinemia) or malignant (B-cell non-Hodgkin lymphoma (B-NHL)) lymphoproliferative disease. METHODS Sixty-six HCV patients were studied, including patients with mixed cryoglobulinemia (n=30), B-NHL (n=15), and no mixed cryog...