Abstract Introduction Current pharmacologic treatments for insomnia are not universally effective, associated with a range of adverse events, can cause daytime impairment, and have the potential to be abused. With no consistent standard care, many patients experience multiple dose changes medication switches. The current study leveraged large-scale, real-world data investigate pharmacological t...

BACKGROUND Despite adequate treatment with antipsychotics, a substantial number of patients with schizophrenia demonstrate only suboptimal clinical outcome. To overcome this challenge, various psychopharmacological combination strategies have been used, including antidepressants added to antipsychotics. METHODS To analyze the efficacy of add-on antidepressants for the treatment of negative, p...