BACKGROUND Biologically based dose-response (BBDR) models can incorporate data on biological processes at the cellular and molecular level to link external exposure to an adverse effect. OBJECTIVES Our goal was to examine the utility of BBDR models in estimating low-dose risk. METHODS We reviewed the utility of BBDR models in risk assessment. RESULTS BBDR models have been used profitably ...

PURPOSE To optimize dose distribution for prostate cancer in low-dose-rate interstitial brachytherapy, we have developed a new algorithm named the Attraction-Repulsion Model. The purpose was to find the optimal source configuration. METHODS AND MATERIALS The Attraction-Repulsion Model is used to optimize the dose distribution by finding the best seed configuration. We arranged grids at interv...

The CERERRA database provides evidence that low-dose rituximab performs as well as the conventional dose in the real world, thus highlighting the possible pharmacoeconomic impact. In clinical trials, it has been shown that rituximab 500 mg twice, performs as well as 1 g twice, 2 weeks apart, in terms of the American College of Rheumatology (ACR)20 and ACR50, but not the ACR70. The choice should...

In mice, five injections of sub-diabetogenic doses of streptozotocin (STZ) may cause diabetes mellitus associated with lymphocyte infiltration of pancreatic islets1*^. There is evidence implicating autoimmune processes in the pathogenesis of this experimental diabetes3 > 4). Significantly, the development of this diabetes was prevented by rabbit anti-mouse lymphocyte serum5). Since deoxyspergua...

In order to evaluate the effect of olive juice on the anxiety and depression behavior, the paper uses olive juice concentrate as experimental material, and uses mice as experimental subjects. Mice are randomly divided into negative, positive, high, medium and low-dose group, administered orally for 7 days. And observe the impact on the mice elevated plus maze test, the opening acts test and for...

BACKGROUND Oral isotretinoin has been used to treat mild to severe hidradenitis suppurativa (HS). OBJECTIVE We reviewed the results of low-dose isotretinoin for 4 to 6 months in the treatment of 68 patients with HS. METHODS This is a retrospective study. Data are presented in terms of response rate, long-term follow-up, and the relation between response rate and severity. RESULTS In 16 pa...

Background: In treating patients with radiation, the degree of accuracy for the delivery of tumor dose is recommended to be within ± 5% by ICRU in report 24. The experimental studies have shown that the presence of low-density inhomogeneity in areas such as the lung can lead to a greater than 30% change in the water dose data. Therefore, inhomogeneity corrections should be used in treatment pla...

introduction: delivering maximum dose to tumor and minimum dose to normal tissues is the most important goal in radiotherapy. according to icru, the maximum acceptable uncertainty in the delivered dose compared to the prescribed dose should be lower than 5%, and this is because of the relationship between absorbed dose, tumor control and normal tissue damage. absorbed dose accuracy is investiga...

PURPOSE The purpose of this study was to measure the dose distributions for different Radiation Oncology Physics and Engineering Services, Australia (ROPES) type eye plaques loaded with I-125 (model 6711) seeds using GafChromic(®) EBT3 films, in order to verify the dose distributions in the Plaque Simulator™ (PS) ophthalmic 3D treatment planning system. The brachytherapy module of RADCALC(®) wa...

PURPOSE Clinical evaluation of a "virtual" methodology for providing 6 degrees of freedom (6DOF) patient set-up corrections and comparison to corrections facilitated by a 6DOF robotic couch. METHODS A total of 55 weekly in-room image-guidance computed tomographic (CT) scans were acquired using a CT-on-rails for 11 pelvic and head and neck cancer patients treated at our facility. Fusion of the...