There are limited treatment options for patients with radioactive iodine refractory, progressive differentiated thyroid cancer. Although there is consensus that multikinase inhibitor therapy should be considered in patients with progressive disease with considerable tumor load or symptomatic disease, uncertainty exists on the optimal timing to treat with a multikinase inhibitor, especially for ...

BACKGROUND AND OBJECTIVES The optimal time of dialysis initiation is unclear. The goal of this analysis was to compare survival outcomes in patients with early and late start dialysis as measured by kidney function at dialysis initiation. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS We performed a retrospective analysis of patients entering the U.S. Renal Data System database from January 1,...

The time of initiation of antiretroviral therapy in HIV-1 infected patients has a determinant effect on the viral dynamics. The question is, how far can the therapy be delayed? Is sooner always better? We resort to clinical data and to microsimulations to forecast the dynamics of the viral load at therapy interruption after prolonged antiretroviral treatment. A computational model previously ev...

INTRODUCTION Initiating dialysis in acute kidney injury (AKI) in an intensive care unit (ICU) remains a subjective clinical decision. We examined factors and practice patterns that influence early initiation of dialysis in ICU patients with acute kidney injury. METHODS An online survey presented nephrologists (international) with three case scenarios with unstated predicted mortality rates of...

Infantile hemangiomas (IH) are vascular tumors that often require timely treatment to reduce morbidity.1,2 The 2019 American Academy of Pediatrics (AAP) Clinical Practice Guidelines (CPG) for the Management IH recommend referral dermatology prior 4 weeks age, enabling initiation.1 This study examines adherence national guidelines and aims identify barriers appropriate timing & treatment. retros...