OBJECTIVE To update the information on long-term safety of biological therapies used for the treatment of rheumatic diseases. METHODS BIOBADASER is a safety registry of biological therapies established by the Spanish Society of Rheumatology. A description of BIOBADASER 2.0, a cohort composed of 14 centres within BIOBADASER is reported from 2000 until 2009. RESULTS The 14 centres have regist...

Teaching cases in medical education are often exhibited through various professional angles, but for patientcentered teaching cases, the division of labor among different specialties is even more important. However, general medical education platforms cannot provide such mechanisms for physicians. Thus, this study adopted a clinical medical education platform “HINTS” to establish a patient-cent...

In 2008, Nicholas Carr published a provocative article titled “Is Google making us stupid?” in which he ponders the effect of the internet and electronic sources generally on the brain. This paper discusses one source specifically, e-books, and explores whether libraries are acting wisely by moving from print to electronic book collections. The topic is considered from the vantage point of the ...

During the last two decades, concentration of measure has been a subject of various exciting developments in convex geometry, functional analysis, statistical physics, high-dimensional statistics, probability theory, information theory, communications and coding theory, computer science, and learning theory. One common theme which emerges in these fields is probabilistic stability: complicated,...

BACKGROUND UK guidelines recommend routine HIV testing in healthcare settings if the local diagnosed HIV prevalence >2/1000 persons. This prospective study assessed the feasibility and acceptability, to patients and staff, of routinely offering HIV tests in four settings: Emergency Department, Acute Care Unit, Dermatology Outpatients and Primary Care. Modelling suggested the estimated prevalenc...

metropolitan regions as a result of the steady stream of urbanization in industrial period which have occurred during 20th century, become the engine of countries growth and development. in the process of formation and development in these areas, spatial structuring that define through two elements of population and activity with the communication structure interacting between them, has been ef...

identifying the change trends in forms of land surface is one of the main topics in geomorphic system. in this view, we try to assess the stability level of geo systems, boundary changes, instability and prediction of surface forms and processes response. this paper tries to conduct a comparative analysis on the geomorphic equilibrium paradigms, critical thresholds, environmental and natural ha...

Security is often viewed as an arms race between attackers, who try to exploit vulnerabilities and security administrators, who try to protect system against these attacks. In this regard, analysis of emerging security trends can be helpful in planning proper countermeasures to ensure security. Several studies and surveys exist that provide statistical information on security trends and issues....

With the deployment of multi-modality and large-scale sensor networks for monitoring air quality, we are now able to collect large and multi-dimensional spatio-temporal datasets. For these sensed data, we present a comprehensive visual analysis approach for air quality analysis. This approach integrates several visual methods, such as map-based views, calendar views, and trends views, to assist...

BACKGROUND Changes in mortality from heart disease, cancer, and stroke over recent decades in many countries have received much attention. However, comprehensive and concurrent analyses of these trends and their effect on total mortality have been lacking. Moreover, the extent to which the trends for one disease may relate to those for another disease is unknown. Concordance of trends for major...