conclusions due to phenolic content, methanolic extract of m. piperita has moderate antibacterial and antifungal properties against the aforementioned gram positive and gram negative bacteria and fungi strains. materials and methods the methanolic extract was prepared by standard procedure, and total phenol, total flavonoid, and total anthocyanin content were determined using a spectrophotomete...

Mycologists and practicing dermatologists frequently have designated as distinct species the downy forms of Trichophyton mentagrophytes that are commonly isolated from chronic ringworm of the feet or toenails and the granular forms of this fungus usually isolated from suppurative ringworm of the beard or scalp. The chief difference between the two types of culture is one of gross colonial form....

Two practical and efficient approaches have been implemented as alternative procedures for the synthesis of naftifine and novel diversely substituted analogues 16 and 20 in good to excellent yields, mediated by Mannich-type reactions as the key step of the processes. In these approaches, the γ-aminoalcohols 15 and 19 were obtained as the key intermediates and their subsequent dehydration cataly...

BACKGROUND Trichophyton verrucosum is a zoophilic fungus with a worldwide distribution. Our aim was to investigate the proliferative effect of antigenic compounds of T. verrucosum on dermis fibro blasts and endothelial cells. METHODS T. verrucosum was cultured in SCC medium and was then transferred to a broth medium. Surface antigens of this fungus were separated using the freeze and thaw met...

Introduction: Tinea capitis is an infection caused by dermatophytes which have a particular affinity for keratin. Its prevalence decreased significantly in developed countries due to the improvement of sanitary conditions and socioeconomic level. However, they are still common in developing countries including Tunisia. The aim of our study was to evaluate the epidemiological, clinical and mycol...

Development of more effective and less toxic antifungal agents is required for the treatment of dermatophytosis. Plants and their extraction preparations have been used as medicines against infectious diseases. In this research, the lemon grass [Cymbopogon citrates DC.) Stapf.], lantana (Lantana camara L.), nerium (Nerium oleander L.), basil (Ocimum basilicum L.) and olive leaves (Olea europaea...

BACKGROUND The treatment of onychomycosis is a challenge and infections are typically more severe and difficult to treat in toenails than in fingernails. OBJECTIVES The current study aimed to investigate the fungicidal effect of ultraviolet radiation on the growth of dermatophytes isolated from nails. PATIENTS AND METHODS Samples from patients with clinical manifestations of onychomycosis w...

OBJECTIVES This study was designed to characterize the role of the human cathelicidin LL-37 in fungal skin infections such as dermatophytosis and tinea versicolor. METHODS The in vitro antimicrobial activity of synthetic antimicrobial peptides including the human cathelicidin LL-37 against Malassezia furfur and several dermatophytes was determined. Immunostaining was performed to determine ex...