o d i a t ryNow Supplement S1 T inea pedis is one of the most commonly encountered foot infections. The fact that in most cases it is easily treatable yet still prevalent in the general population suggests that it is often undiagnosed or remains untreated by health care p rofessionals and patients. The most common agent is Trichophyton rubrum, which is often mistaken for dry skin in its present...

The essential oil and the aqueous, hexane and methanolic fractions from Hyptis ovalifolia leaves were evaluated for their antifungal activity in vitro against 60 strains of dermatophytes: 10 strains of Microsporum canis, 10 of M. gypseum, 20 of Trichophyton rubrum and 20 of T. mentagrophytes. The extracts inhibited growth of the dermatophytes tested at different concentrations. The most biologi...

A 60-year-old Japanese man presented with multiple subcutaneous nodules in his left groin. Histologically, the nodules consisted of suppurative granulomas and abscesses not involving the hair follicles. Trichophyton rubrum TWCC57922 was detected by fungal culture and polymerase chain reaction (PCR) sequencing of the rDNA genes. We diagnosed these nodules as deeper dermal dermatophytosis, a rare...

A survey of Raktaja Krimis of Chhindwara was made during July, 1986 to June, 1987. Tinea infections were abundant followed by Tinea cruris, Tinea pedis, Tinear capitis, Tinea barbae, and Tinea unguinum. Tinea infections were common among the youth between 21 - 30 years. The percentage wise tinea infections were as follows : Trichophyton rubrum (64.5%), T. mentagrophytes (5.37%), T. violaceum (1...

We investigated the biochemical basis for resistance in six sequential clinical isolates of Trichophyton rubrum, from the same patient, which exhibited high-level primary resistance to terbinafine. Cellular ergosterol biosynthesis was measured by incorporation of [14C]acetate, and microsomal squalene epoxidase was assayed by conversion of [3H]squalene to squalene epoxide and lanosterol. Direct ...

Dermatophyte infections are one of the most common superficial fungal infections. However dermatophytes invade subcutaneous tissues rarely. We report herein a 65 year-old woman who was as a known case of rheumatoid arthritis (For 10 years) and taking immunosuppressive drugs, presented with multiple nodules and sinuses in the knee area. Histopathologic studies revealed PAS positive granulomas an...

The application of photosensitizers for the treatment of fungal infections is a new and promising development within the field of photodynamic treatment (PDT). Dermatophytes, fungi that can cause infections of the skin, hair and nails, are able to feed on keratin. Superficial mycoses are probably the most prevalent of infectious diseases in all parts of the world. One of the most important rest...

<p><em>Ganoderma lucidum (lingzhi) can be used as traditional medicine. This mushroom has many properties, one of which is an antimicrobial. Antimicrobial functions antibacterial, antiviral, and antifungal. Lingzhi contains organic alkaloid compounds, flavonoids, triterpenoids. One the bacteria that often cause disease in Indonesia Salmonella sp several dermatophyte diseases caused ...

OBJECTIVES Recently, bergamot oil was shown to be a potent antifungal agent in vitro against clinically important Candida species. In this study, the activities of bergamot natural essence and its furocoumarin-free and distilled extracts on dermatophytes such as Trichophyton, Microsporum and Epidermophyton species were investigated. METHODS In vitro susceptibility testing assays on 92 clinica...

BACKGROUND Dermatophytes are fungi that can cause infections of skin, hair and nails because of their ability to feed on keratin. Superficial mycoses are among the most prevalent infectious diseases worldwide. Two important restrictions of current therapeutic options are the recurrence of the infection and prolonged treatment. This is especially true for infections caused by Trichophyton rubrum...