Th e aerial parts and seeds of Sophora alopecuroides L. var. alopecuroides growing in Turkey were investigated for their alkaloid compositions and antimicrobial activities. Th e alkaloid extracts were analysed by capillary gas chromatography-mass spectrometry (GC-MS). Th e main components were identifi ed as sophoridine (33.07%), matrine (24.03%), and sophocarpine (8.01%) in the aerial parts, a...

To study the antitumor activity of alkaloid extracted from Oxytropis ochrocephala and its possible mechanism, we observed the effect of alkaloid on tumor weight and expression of PCNA and p53 in mice bearing H(22) hepatocellular carcinoma by means of immunohistochemistry SP method. After treatment with alkaloid from Oxytropis ochrocephala, the results showed that alkaloid administration (25 and...

Three ergoline alkaloids producing Claviceps strains easily formed protoplasts when treated with snail digestive extract ex Helix pomatia. Colonies obtained after regeneration of protoplasts were monitored for alkaloid production. Among the regenerated progeny strains could be iso­ lated which differ considerably in the quantity of ergolines and the composition of the alkaloid mixture compared ...

A new Erythrina alkaloid glycoside, named erythraline-11β-O-glucopyranoside, was isolated from the seeds of Erythrina crista-galli L., together with five known Erythrina alkaloids and an indole alkaloid. The structure of the new alkaloid glycoside was elucidated by spectroscopic methods, and all of the compounds were evaluated for their antiviral activity against tobacco mosaic virus.

Fifty three alkaloids were identified in the organs (roots, stems, leaves, flowers, and seeds) of Datura innoxia by GC/MS. Seventeen of them are reported for the first time for this species and one nor-derivative, 3-phenylacetoxynortropane (28), for the genus Datura. Furthermore, four new tropane esters were tentatively identified as 3-acetoxy-6,7-epoxytropane (acetylscopine) (10), 3-acetoxy-6-...

Mitragyna speciosa Korth. leaves have been traditionally used by Malay and Thai natives for its opiumlike effect and coca-like stimulant ability to enhance tolerance for hard work. Mitragynine is the major indole alkaloid in this plant. In the present study, we investigated the effects of the alkaloid extract of M. speciosa leaves and its major alkaloid mitragynine on exploratory behaviour, sho...

In the last decades, data on the content of toxic alkaloids in ergot and the relationship of the ergot contamination in rye and the alkaloid content in ergot has been scarce. Therefore, the level of ergot contamination (g/kg rye) and the alkaloid contents (mg/kg ergot) of ergot grown on 7, 21 and 24 artificially infected rye varieties at three German locations in 2002, 2003 and 2004 were determ...

An efficient and highly diastereoselective method for the construction of the hydroxylated tropane skeleton is described. The method features a new intramolecular reductive coupling reaction of N-acyl N,O-acetal with aldehyde, cooperatively mediated by BF(3)·OEt(2) and SmI(2). On the basis of this method, a new enantioselective total synthesis of (-)-Bao Gong Teng A has been accomplished.