Cerebral hypoperfusion during cardiopulmonary bypass surgery has been thought to be a factor in the aetiology of brain damage with evidence of post-operative neurological deficits. Cardiac-specific biomarkers such as troponin-I, troponin-T and CK-MB have been used extensively to predict myocardial injury and ischaemia. This prospective study investigated the level of troponin-I release in both ...

INTRODUCTION The prognosis in patients with acute coronary syndrome without persistent ST segment elevation (NSTEACS) differs depending on cardiac troponin levels. Clinical practice guidelines published by the Spanish Society of Cardiology and the ACC/AHA consider patients with NSTEACS and markedly elevated troponin levels as high risk patients. The aim of this study was to identify factors rel...

OBJECTIVES This study was done to determine the effects of angiotensin-converting enzyme (ACE) inhibition and other clinical factors on troponin release in non-ST-elevation acute coronary syndrome (ACS). BACKGROUND Troponin is now widely used as a marker of risk in ACS, but determinants of its release have not been defined. METHODS This was a prospective cohort study of 301 consecutive pati...

BACKGROUND Elevation of baseline cardiac troponin in patients presenting with acute coronary syndromes (ACS) confers an adverse prognosis. The prognostic value of troponin elevation in patients with chronic kidney disease (CKD) and ACS is less certain. METHODS AND RESULTS In the ACUITY (Acute Catheterization and Urgent Intervention Triage strategy) trial, 13 819 patients with moderate and hig...

The present study evaluated the prognosis at different troponin concentrations regardless of the underlying diagnosis in an unselected group of patients admitted to the coronary care unit (CCU) and whether the prognosis is dependent on the cause of the troponin increase. Troponin I was measured with the Stratus CS analyzer (Dade Behring) in 468 consecutively and unselected patients admitted to ...

Troponin, myeloperoxidase (MPO) and homocysteine are markers for the diagnosis and characterization of cardiac diseases. While cardiac troponin assays are established tools for exclusion of coronary disease, MPO is a new powerful marker for the identification of high risk patients with atherosclerotic plaque ruptures. Homocysteine is a versatile marker for cardiovascular events and dementia. Ab...

BACKGROUND Myocardial infarction can be difficult to diagnose after lung surgery. As recent diagnostic criteria emphasize serum cardiac markers (in particular serum troponin) we set out to evaluate its clinical utility and to establish the long term prognostic impact of detected abnormal postoperative troponin levels after lung resection. METHODS We studied a historic cohort of patients with ...

The concept and use of the 99th percentile for interpretation of cardiac troponin was introduced with the redefinition of myocardial infarction in 2000, a time when few assays could detect cardiac troponin at the 99th percentile and none could meet the criteria of an assay CV of 10% at this concentration. There have been many reports of the 99th percentile providing useful information toward de...

Background: Cardiac troponin test is used in detecting various heart disorders. The objective of this study was to establish normal reference levels for serum cardiac Troponin I which could be utilized for selection of vaccines and determine any electrocardiogram (EKG) changes among healthy volunteers. Methods: A total of 263 healthy blood donors from Dar es Salaam, Tanzania were included in th...

Cardiac troponin, a heterotrimeric protein complex that regulates heart contraction, represents an attractive target for the development of drugs for treating heart disease. Cardiovascular diseases are one of the chief causes of morbidity and mortality worldwide. In France, however, the death rate from heart disease is remarkably low relative to fat consumption. This so-called "French paradox" ...