administration of the TREM-1 decoy receptor rTREM-1/ Fc attenuated the proinflammatory cytokine response, improving the outcome [3] . S. pyogenes also produces several proteases and two of these have distinct activities against immunoglobulins (IgGs). The classical cysteine proteinase of S. pyogenes is SpeB, having broad proteolytic activities including IgG degradation [4] . In addition, S. pyo...

Arcanobacterium pyogenes, a common inhabitant of the mucosal surfaces of livestock, is also a pathogen associated with a variety of infections. In livestock, A. pyogenes is exposed to antimicrobial agents used for prophylaxis and therapy, notably tylosin, a macrolide used extensively for the prevention of liver abscessation in feedlot cattle in the United States. Many, but not all, tylosin-resi...

Some isolates of the significant human pathogen Streptococcus pyogenes, including virulent strains of the M1 serotype, secrete protein SIC. This molecule, secreted in large quantities, interferes with complement function. As a result of natural selection, SIC shows a high degree of variation. Here we provide a plausible explanation for this variation and the fact that strains of the M1 serotype...

Strep throat causing Streptococcus pyogenes was detected in vitro and in simulated clinical samples by performing touch spray ionization-mass spectrometry. MS analysis took only seconds to reveal characteristic bacterial and human lipids. Medical swabs were used as the substrate for ambient ionization. This work constitutes the initial step in developing a non-invasive MS-based test for clinica...

Streptococcus pyogenes (group A streptococcus) causes human skin and throat infections as well as highly invasive diseases including necrotizing fasciitis. Group A streptococcal infections and invasive disease have made a resurgence in developed countries during the past two decades. S. pyogenes use multiple pathways for the acquisition and activation of human plasminogen, securing potent prote...

Introduction The acronym PANDAS reveals a pediatric autoimmune neuropsychiatric disorder associated with Streptococcus pyogenes infection. This disorder is defined by: (a) the presence of obsessive-compulsive disorder (OCD) or tics; (b) abrupt onset and remitting/relapsing course; (c) prepuberal onset of all symptoms; (d) temporal association with a group A b-hemolytic S. pyogenes infection; (e...

Objective. To determine in vitro activity of thiamphenicol and other clinically available antimicrobials against clinical isolates Haemophilus influenzae, Streptococcus pneumoniae pyogenes. Materials Methods. We included the study 875 from 20 Russian cities during 2018–2019. Among tested strains, 126 were H. 389 – S. pneumoniae, 360 Antimicrobial susceptibility testing was performed using broth...

Ethanol extract of Rhodomyrtus tomentosa (Aiton) Hassk. leaf was evaluated for antibacterial activity against 47 clinical isolates of Streptococcus pyogenes. The extract exhibited good anti-S. pyogenes activity against all the tested isolates with similar minimum inhibitory concentration (MIC, 3.91-62.5 μg mL(-1)) and minimum bactericidal concentration (MBC, 3.91-62.5 μg mL(-1)) ranges. No surv...

Immunity to common bacteria requires the generation of antibodies that promote opsonophagocytosis and neutralise toxins. Pooled human immunoglobulin is widely advocated as an adjunctive treatment for clinical Streptococcus pyogenes infection however, the protein targets of the reagent remain ill defined. Affinity purification of the anti-streptococcal antibodies present within pooled immunoglob...