Thymidylate synthase (TS), which catalyzes the de novo synthesis of dUMP, is an important target for cancer therapy. In this report, the effects of 5-fluorouracil (5-FU) and ZD1694 on the regulation of TS gene expression were evaluated in zebrafish embryos. Our results revealed that the expression of TS was increased by about six-fold when embryos were treated with 1.0 microM 5-FU and there was...

Background: Auto-immunization was proposed as the mechanism of contralateral testicular damage following unilateral vas deferens injuries. The objective of this experimental in vitro study was to elucidate the effect of tacrolimus (TS) as a powerful immunosuppressant on contralateral epididymal sperm fertilizing capacity following unilateral vas deferens obstruction (UVO) in mice. Materials and...

conclusions it seems that testosterone in low dose, i.e. physiologic dose, protects kidneys against cp-induced nephrotoxicity; however, special care is needed in cp therapy of patients with high levels of ts. results cp increased the serum levels of blood urea nitrogen (bun), creatinine (cr), and malondialdehyde (smda) as well as kidney weight (kw), bodyweight (bw) loss, and kidney tissue damag...

Thymidylate synthase (TS) is the only de novo source of thymidylate (dTMP) for DNA synthesis and repair. Drugs targeting TS protein are a mainstay in cancer treatment, but off-target effects and toxicity limit their use. Cytosolic thymidine kinase (TK1) and mitochondrial thymidine kinase (TK2) contribute to an alternative dTMP-producing pathway, by salvaging thymidine from the tumor milieu, and...

et al. Spinal brucellosis. Br J Rheumatol 1987;26:28-30. 10. Al-Rawi ZS, Al-Khateeb N, Khalifa SJ. Brucella arthritis among Iraqi patients. Br J Rheumatol 1987;26:24-7. 11. Hodinka L, Gomor B, Meretey K, et al. HLA B27 associated with spondyloarthritis in chronic brucellosis. Lancet 1978;i:499. 12. Alarcon GS, Bocanegra TS, Gotuzzo E, etal. Reactive arthritis associated with brucellosis: HLA st...

The Commission has issued the enclosed Amendment No. 198 to Facility Operating License No. DPR-72 for Crystal River Unit 3 (CR-3). The amendment consists of changes to the existing Technical Specifications (TS) in response to your letter dated March 21, 2001, as supplemented June 28, 2001. Florida Power Corporation (FPC) submitted a request for changes to the CR-3 Improved Technical Specificati...

Graeme Henkelman,1,* Blas P. Uberuaga,2 Duncan J. Harris,3 John H. Harding,4 and Neil L. Allan5 1Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712-0165, USA 2Material Science and Technology Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA 3Department of Physics and Astronomy, University College London, Gower St., London W...