This study was performed to estimate the rate of boosted reaction in the two-step tuberculin skin test (TST) and to evaluate the associated factors among military personnel of South Korea, which has an intermediate burden of tuberculosis (TB) and a routine bacille Calmette-Guerin (BCG) vaccination policy. Two-step TST was performed on 264 military personnel who did not have a history of close c...

The mainstay of tuberculosis diagnosis in cattle and deer has been the tuberculin skin test. Recent advances have allowed the incorporation of blood based assays to the diagnostic arsenal for both cattle and deer. Use of defined and specific antigens has allowed for improved specificity of cell mediated assays in both cattle and deer and advances in antibody tests for tuberculosis have potentia...

Classical transition state theory (TST) is the cornerstone of reaction-rate theory. It postulates a partition of phase space into reactant and product regions, which are separated by a dividing surface that reactive trajectories must cross. In order not to overestimate the reaction rate, the dynamics must be free of recrossings of the dividing surface. This no-recrossing rule is difficult (and ...

THE development of erythema is often a striking feature of the reaction to tuberculin. It occurs in the cutaneous test of Von Pirquet, and its development was the criterion of positivity in the conjunctival test of Wolff-Eisner and Calmette. It is usually well developed in the test which superseded both of these, the intracutaneous test of Mantoux. Over the years, however, particularly with the...

T-lymphocytes previously sensitized by an antigen undergo blastic transformation and produce IFN’r when stimulated by the same antigen. We studied the lymphoblastic response to PPD and IFNT production in pleural fluid and peripheral blood of 41 patients (15 with tuberculosis pleural effusion, 13 with nontuberculous pleurisy and positive tuberculin skin test, and 13 with tuberculin-negative nont...

OBJECTIVE To determine the prevalence of cutaneous anergy in pregnant and nonpregnant women who are seropositive for human immunodeficiency virus. METHODS AND MATERIALS The medical records of 159 women seropositive for human immunodeficiency virus were reviewed. Demographic characteristics and tuberculin skin test results were abstracted from the chart. Tuberculin skin testing was performed b...

Infectivity of Sputum smear positive patients with tuberculosis for household contacts was assessed before diagnosis and during domiciliary treatment. Intracutaneous tuberculin test, sputum and radiological examinations were done in all cases and their house-hold contacts initially; and were repeated for contacts every six months during two years follow-up. Initially 244 (56%) contacts gave pos...

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To the editor: We have read with interest the excellent article by Alemany et al, “Assessment of Nurses’ Understanding of Tuberculin Testing at a General Hospital”1 and are sending this letter in the belief that the results of a recent study we have made may complement the authors’ conclusions. In spite of the fact that tuberculin testing was introduced almost a century ago by Charles Mantoux a...

BACKGROUND Phoenix Firefighters have had abnormally high rates of tuberculin skin test (TBST) results on medical surveillance. The objectives of this study were to evaluate our firefighters using QuantiFERON-TB (QFT), comparing the results to their TBST results. METHODS Using QFT results obtained during the study, we compared previously positive TBST responders (Cases) to negative responders ...