A new synthesis of sulfonamides has been developed via an iodine-catalyzed sulfonylation of amines with arylsulfonyl hydrazides. This metal-free strategy employs readily accessible and easy to handle starting materials, catalysts and oxidants, and can be easily conducted under mild conditions, providing a convenient access to a wide range of sulfonamides in moderate to excellent yields within a...

Facile reactivity of hydrazides and aldehydes was explored as potential coupling partners for incorporation into M(CO)(3) (M = Re, (99m)Tc) based radiopharmaceuticals. Both 'click, then chelate' and 'prelabel, then click' synthetic routes produced identical products in high yields and lacked metal-hydrazide/-hydrazone interactions, highlighting the potential of this click strategy.

A new cascade three-component halosulfonylation of 1,7-enynes for efficient synthesis of densely functionalized 3,4-dihydroquinolin-2(1H)-ones has been established from readily accessible arylsulfonyl hydrazides and NIS (or NBS). The reaction pathway involves in situ-generated sulfonyl radical-triggered α,β-conjugated addition/6-exo-dig cyclization/radical coupling sequence, resulting in contin...

Tuberculosis is one of the top reasons death all over planet. Mycobacterium tuberculosis, bacteria that infects lungs, what causes it. For professionals working in medical field, accurately identifying and timely predicting tuberculosis are major challenges. The course treatment also varies from patient to since occasionally a develops drug resistance. Doctors will be given algorithmic support ...

BACKGROUND Combination antiretroviral therapy (cART) has progressively decreased mortality of HIV-associated tuberculosis .To date, however, limited data on tuberculosis treatment outcomes among coinfected patients who are not ART-naive at the time of tuberculosis diagnosis are available. METHODS A multicenter, observational study enrolled 246 HIV-infected patients diagnosed with tuberculosis...

OBJECTIVE To analyze the impact that the 2009 changes in tuberculosis treatment in Brazil had on the rates of cure, tuberculosis recurrence, mortality, treatment abandonment, and multidrug-resistant tuberculosis (MDR-TB). METHODS An ordinary least squares regression model was used in order to perform an interrupted time series analysis of secondary data collected from the Brazilian Tuberculos...

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis complex mycobacteria. Extrapulmonary tuberculosis usually develops more than two years after infection or many years later. Factors favoring onset of the disease are malnutrition, older age, renal failure, diabetes, cancer, immunosuppression and biological treatment, e.g. tumor necrosis factor α (TNF-α) inhibitors. The p...

objective: dysfunctional beliefs of tuberculosis patients have pivotal role in treatment and development of their serious psychiatric problems. cognitive group psychotherapy has been utilized to manage the dysfunctional beliefs. methods: in a quasi-experimental study and a pretest and posttest design, 24 male tubercular patients were selected by convenient sampling and then randomly assigned to...

Tuberculosis is a major health problem throughout the world. Inhalation is the most susceptible pathway of Mycobacterium tuberculosis infection, pulmonary tuberculosis being the predominant one. Apart from this, Extra Pulmonary Tuberculosis may also arise as a result of the reactivation of tuberculous focus after dissemination from a chief focus, being a manifestation of tuberculosis infecting ...