نتایج جستجو برای: tumor associated macrophages
تعداد نتایج: 1906285 فیلتر نتایج به سال:
Radiotherapy (RT) is broadly used for cancer treatment, including early breast (eBRCA) and rectal cancers (RC). However, many components of the tumor microenvironment (TME) contribute to RT resistance. induces cell death resulting in antigen release that triggers recruitment a variety immune cells can act either stimulatory or suppressive on anti-tumor immunity. A deeper understanding immunity ...
Tumor vascularization is a highly complex process that involves the interaction between tumors and their surrounding stroma, as well as many distinct angiogenesis-regulating factors. Tumor associated macrophages (TAMs) represent one of the most abundant cell components in the tumor environment and key contributors to cancer-related inflammation. A large body of evidence supports the notion that...
Ovarian cancer is the leading cause of death in women with gynecological malignancy and improvements in current treatments are needed. As with many other solid cancers, the ovarian tumor microenvironment is emerging as a key player in tumor progression and a potential therapeutic target. The tumor microenvironment contains several non-malignant cell types that are known to contribute to tumor p...
Carcinogenesis is a multistep process. Besides somatic mutations in tumor cells, stroma-associated immunity is a major regulator of tumor growth. Tumor cells produce and secrete diverse mediators to create a local microenvironment that supports their own survival and growth. It is becoming apparent that iron acquisition, storage, and release in tumor cells is different from healthy counterparts...
Cell-to-cell interactions (CCIs) through ligand-receptor (LR) pairs in the tumor microenvironment underlie poor prognosis of pancreatic ductal adenocarcinoma (PDAC). However, there is scant knowledge association CCIs with PDAC prognosis, which critical to identification potential therapeutic candidates. Here, we sought identify LR associated patient by integrating survival analysis and single-c...
Tumor growth is associated with aberrant myelopoiesis, including the accumulation of CD11b(+)Gr-1(+) myeloid-derived suppressor cells (MDSCs) that have the potential to promote tumor growth. However, the identity, growth, and migration of tumor-associated MDSCs remain undefined. We demonstrate herein that MDSCs at tumor site were composed primarily of bone marrow-derived CD11b(+)Gr-1(hi)Ly-6C(i...
Tumor-associated macrophages are a prominent component of ovarian cancer stroma and contribute to tumor progression. B7-H4 is a recently identified B7 family molecule. We show that primary ovarian tumor cells express intracellular B7-H4, whereas a fraction of tumor macrophages expresses surface B7-H4. B7-H4+ tumor macrophages, but not primary ovarian tumor cells, suppress tumor-associated antig...
Cancer stem cells are currently considered to contribute to the aggressiveness and therapeutic resistance of pancreatic cancer, providing new hope for the cure of this disease and resulting in a growing body of mechanistic research. Solid tumors are heterogeneous cellular entities that contain malignant cells and a surrounding nonmalignant stroma. An abundant tumor stroma with a high density of...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید